ArticleThe Journal of clinical investigation2011
Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Elevated hypoxia-inducible factor-1α in pediatric patients with patent ductus arteriosus: a pilot study.Pharmacological reports : PR · 2026Article
- Bronchial anastomotic complications as a microvascular disruption in a mouse model of airway transplantation.Frontiers in immunology · 2025Review
- Targeting Interleukin-10 Restores Graft Microvascular Supply and Airway Epithelium in Rejecting Allografts.International journal of molecular sciences · 2022Article
- Article
- Regulation of Endothelial-to-Mesenchymal Transition by MicroRNAs in Chronic Allograft Dysfunction.Transplantation · 2019Article
- Airway hypoxia in lung transplantation.Current opinion in physiology · 2019Article
- The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation.Journal of cardiothoracic surgery · 2019Article
- Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium.American journal of respiratory cell and molecular biology · 2016Article
- Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation.American journal of respiratory and critical care medicine · 2016Article
- Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016Review
- The endothelial ADMA/NO pathway in hypoxia-related chronic respiratory diseases.BioMed research international · 2014Review
- IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Five-year update on the mouse model of orthotopic lung transplantation: Scientific uses, tricks of the trade, and tips for success.Journal of thoracic disease · 2012Article
- Review
- Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.Journal of dermatological science · 2012Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Chronic lung allograft rejection, known as obliterative bronchiolitis (OB), is the leading cause of death in lung transplant patients. Although OB pathogenesis is not fully understood, in this issue of the JCI, Jiang and colleagues report that tissue hypoxia resulting in dysfunctional airway microvasculature precedes the airway fibrosis characteristic of OB. In addition, a relative deficiency of allograft endothelial cell-derived HIF-1α contributes to this process. Data showing that overexpressing HIF-1α restores the microvascular airway normoxia and prevents airway fibrosis highlight a novel role for vascular biology in OB pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.