ArticleProceedings of the National Academy of Sciences of the United States of America2011
Relating domain size distribution to line tension and molecular dipole density in model cytoplasmic myelin lipid monolayers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 69 citations in OpenAlex.
- Using diffusion-induced growth instabilities to measure line tension at liquid condensed-liquid expanded domain boundaries.Journal of colloid and interface science · 2026Article
- Curvature and shape relaxation in surface-viscous domains.Physical review fluids · 2023Article
- Spontaneous evolution of equilibrium morphology in phospholipid-cholesterol monolayers.Science advances · 2022Article
- Incorporation of Molecular Reorientation into Modeling Surface Pressure-Area Isotherms of Langmuir Monolayers.Molecules (Basel, Switzerland) · 2021Article
- Lateral heterogeneity and domain formation in cellular membranes.Chemistry and physics of lipids · 2020Article
- Shape morphology of dipolar domains in planar and spherical monolayers.The Journal of chemical physics · 2020Article
- Comparison of Line Tension Measurement Methods for Lipid Monolayers at Liquid-Liquid Coexistence.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- The mechanobiology of actin cytoskeletal proteins during cell-cell fusion.Journal of the Royal Society, Interface · 2019Article
- Interfacial curvature effects on the monolayer morphology and dynamics of a clinical lung surfactant.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Lipid Order Degradation in Autoimmune Demyelination Probed by Polarized Coherent Raman Microscopy.Biophysical journal · 2017Article
- Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid Membranes.Biophysical journal · 2017Article
- Line Tension Controls Liquid-Disordered + Liquid-Ordered Domain Size Transition in Lipid Bilayers.Biophysical journal · 2017Article
- Functional organization of the HIV lipid envelope.Scientific reports · 2016Article
- Interface-mediation of lipid bilayer organization and dynamics.Physical chemistry chemical physics : PCCP · 2016Article
- Real-time intermembrane force measurements and imaging of lipid domain morphology during hemifusion.Nature communications · 2015Article
- Phospholipid composition modulates carbon nanodiamond-induced alterations in phospholipid domain formation.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Visualizing monolayers with a water-soluble fluorophore to quantify adsorption, desorption, and the double layer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Influence of molecular coherence on surface viscosity.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Lipid domains control myelin basic protein adsorption and membrane interactions between model myelin lipid bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Monolayer spontaneous curvature of raft-forming membrane lipids.Soft matter · 2013Article
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
We fit the size distribution of liquid-ordered (L(o)) domains measured from fluorescence images of model cytoplasmic myelin monolayers with an equilibrium thermodynamic expression that includes the competing effects of line tension, λ, dipole density difference, Δm, and the mixing entropy. From these fits, we extract the line tension, λ, and dipole density difference, Δm, between the L(o) and liquid-disordered (L(d)) phases. Both λ and Δm decrease with increasing surface pressure, , although λ/Δm(2) remains roughly constant as the monolayer approaches the miscibility surface pressure. As a result, the mean domain size changed little with surface pressure, although the polydispersity increased significantly. The most probable domain radius was significantly smaller than that predicted by the energy alone, showing that the mixing entropy promotes a greater number of smaller domains. Our results also explain why domain shapes are stable; at equilibrium, only a small fraction of the domains are large enough to undergo theoretically predicted shape fluctuations. Monolayers based on the composition of myelin from animals with experimental allergic encephalomyelitis had slightly lower values of λ and Δm, and a higher area fraction of domains, than control monolayers at all . While it is premature to generalize these results to myelin bilayers, our results show that the domain distribution in myelin may be an equilibrium effect and that subtle changes in surface pressure and composition can alter the distribution of material in the monolayer, which will likely also alter the interactions between monolayers important to the adhesion of the myelin sheath.
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