ArticleThe Journal of cell biology2011
Peroxisome reintroduction in Hansenula polymorpha requires Pex25 and Rho1.
Article in The Journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Phosphorylation of Pex11p does not regulate peroxisomal fission in the yeast Hansenula polymorpha.Scientific reports · 2015Article
- Evolving models for peroxisome biogenesis.Current opinion in cell biology · 2014Review
- Preperoxisomal vesicles can form in the absence of Pex3.The Journal of cell biology · 2014Article
- A critical reflection on the principles of peroxisome formation in yeast.Frontiers in physiology · 2014Review
- Peroxisomes take shape.Nature reviews. Molecular cell biology · 2013Review
- Emerging role of the endoplasmic reticulum in peroxisome biogenesis.Frontiers in physiology · 2013Review
- Lumenal peroxisomal protein aggregates are removed by concerted fission and autophagy events.Autophagy · 2013Article
- Peroxisomal catalase deficiency modulates yeast lifespan depending on growth conditions.Aging · 2013Article
- Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store 'em up or burn 'em down.Genetics · 2013Review
- From networks of protein interactions to networks of functional dependencies.BMC systems biology · 2012Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- De novo peroxisome biogenesis in Penicillium chrysogenum is not dependent on the Pex11 family members or Pex16.PloS one · 2012Article
- A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomes.Traffic (Copenhagen, Denmark) · 2012Article
- Membrane elongation factors in organelle maintenance: the case of peroxisome proliferation.Biomolecular concepts · 2011Article
Corrections and comments
- Retraction · 2015-08-03Error in Data · Error in Image · Error in Methods · Unreliable Data · Unreliable Image · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified two proteins, Pex25 and Rho1, which are involved in reintroduction of peroxisomes in peroxisome-deficient yeast cells. These are, together with Pex3, the first proteins identified as essential for this process. Of the three members of the Hansenula polymorpha Pex11 protein family-Pex11, Pex25, and Pex11C-only Pex25 was required for reintroduction of peroxisomes into a peroxisome-deficient mutant strain. In peroxisome-deficient pex3 cells, Pex25 localized to structures adjacent to the ER, whereas in wild-type cells it localized to peroxisomes. Pex25 cells were not themselves peroxisome deficient but instead contained a slightly increased number of peroxisomes. Interestingly, pex11 pex25 double deletion cells, in which both peroxisome fission (due to the deletion of PEX11) and reintroduction (due to deletion of PEX25) was blocked, did display a peroxisome-deficient phenotype. Peroxisomes reappeared in pex11 pex25 cells upon synthesis of Pex25, but not of Pex11. Reintroduction in the presence of Pex25 required the function of the GTPase Rho1. These data therefore provide new and detailed insight into factors important for de novo peroxisome formation in yeast.
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