ReviewMolecular human reproduction2011
Mathematical modeling of calcium signaling during sperm hyperactivation.
Review in Molecular human reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Cpne1 deficiency preserves sperm motility under CaThe Journal of reproduction and development · 2024Article
- Comparative characteristics between calyculin A-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa.The Journal of reproduction and development · 2023Article
- Involvement of CaThe Journal of reproduction and development · 2022Article
- Review
- Hyperactivation is sufficient to release porcine sperm from immobilized oviduct glycans.Scientific reports · 2022Article
- HDL mediates reverse cholesterol transport from ram spermatozoa and induces hyperactivated motility.Biology of reproduction · 2021Article
- The Presence of Seminal Plasma during Liquid Storage of Pig Spermatozoa at 17 °C Modulates Their Ability to Elicit In Vitro Capacitation and Trigger Acrosomal Exocytosis.International journal of molecular sciences · 2020Article
- Flagellar hyperactivation of bull and boar spermatozoa.Reproductive medicine and biology · 2018Review
- Computational imaging of sperm locomotion.Biology of reproduction · 2017Article
- Protein biomarkers for male artificial insemination subfertility in bovine spermatozoa.Reproductive medicine and biology · 2017Review
- Search for a small egg by spermatozoa in restricted geometries.Journal of mathematical biology · 2016Article
- Identification, localization, and functional analysis of the homologues of mouse CABS1 protein in porcine testis.Experimental animals · 2016Article
- Regulation and roles of Ca2+ stores in human sperm.Reproduction (Cambridge, England) · 2015Review
- Evaluating the effects of Escanbil (Calligonum) extract on the expression level of Catsper gene variants and sperm motility in aging male mice.Iranian journal of reproductive medicine · 2014Article
- NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.Molecular biology of the cell · 2014Article
- Article
- The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation.Human reproduction (Oxford, England) · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the cumulus matrix. It is absolutely required for sperm penetration of the oocyte zona pellucida. In order for sperm to hyperactivate, cytoplasmic Ca(2+) levels in the flagellum must increase. The major mechanism for providing Ca(2+) to the flagellum, at least in mice, are CatSper channels in the plasma membrane of the principal piece of the flagellum, because sperm from CatSper null males are unable to hyperactivate. There is some evidence for the existence of other types of Ca(2+) channels in sperm, but their roles in hyperactivation have not been clearly established. Another Ca(2+) source for hyperactivation is the store in the redundant nuclear envelope of sperm. To stabilize levels of cytoplasmic Ca(2+), sperm contain Ca(2+) ATPase and exchangers. The interactions between channels, Ca(2+) ATPases, and exchangers are poorly understood; however, mathematical modeling can help to elucidate how they work together to produce the patterns of changes in Ca(2+) levels that have been observed in sperm. Mathematical models can reveal interesting and unexpected relationships, suggesting experiments to be performed in the laboratory. Mathematical analysis of Ca(2+) dynamics has been used to develop a model for Ca(2+) clearance and for CatSper-mediated Ca(2+) dynamics. Models may also be used to understand how Ca(2+) patterns produce flagellar bending patterns of sperm in fluids of low and high viscosity and elasticity.
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Registered trials
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