ArticleMolecular and cellular biology1990
Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Expression of Annexin A2 Promotes Cancer Progression in Estrogen Receptor Negative Breast Cancers.Cells · 2020Article
- Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.Virology journal · 2017Article
- NOX1 supports the metabolic remodeling of HepG2 cells.PloS one · 2015Article
- Annexin A2 heterotetramer: structure and function.International journal of molecular sciences · 2013Article
- Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma.Carcinogenesis · 2013Article
- Article
- Effect of shRNA mediated down-regulation of Annexin A2 on biological behavior of human lung adencarcinoma cells A549.Pathology oncology research : POR · 2012Article
- Annexin II binds to capsid protein VP1 of enterovirus 71 and enhances viral infectivity.Journal of virology · 2011Article
- Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myeloma.International journal of hematology · 2009Article
- Annexin II represents metastatic potential in clear-cell renal cell carcinoma.British journal of cancer · 2009Article
- Role of Annexin-II in GI cancers: interaction with gastrins/progastrins.Cancer letters · 2007Review
- Comparison of annexin II, p63 and alpha-methylacyl-CoA racemase immunoreactivity in prostatic tissue: a tissue microarray study.Journal of clinical pathology · 2007Article
- Article
- Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis.Oncogene · 2004Article
- Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration.Oncogene · 2003Article
- Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress.The American journal of pathology · 2000Article
- Specific down-regulation of annexin II expression in human cells interferes with cell proliferation.Molecular and cellular biochemistry · 1999Article
- Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma.The Journal of clinical investigation · 1996Article
- Annexin II up-regulates cellular levels of p11 protein by a post-translational mechanisms.The Biochemical journal · 1996Article
- The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
A basic phosphoprotein defined by a monoclonal antibody named AF5 was found to be highly abundant in human hepatocellular carcinoma by Western immunoblotting. Under the same conditions, the levels of this phosphoprotein were low or undetectable in normal liver extracts. The AF5 antibody was used to screen a cDNA expression library of a human hepatoma cell line named FOCUS. A 960-base-pair cDNA was isolated and found to be a partial cDNA encoding the human protein-tyrosine kinase substrate p36, also known as lipocortin II. p36 expression was highly abundant in hepatocellular carcinomas at both the transcript and protein levels. Its expression was not induced significantly during rat liver regeneration following a partial hepatectomy. These results suggest that the induction of p36 expression is associated with malignant transformation of hepatocytes. p36 was previously shown to be phosphorylated upon transformation of normal fibroblasts by retroviral oncogenes without significant modulation of expression. We report here the initial description of the association of increased p36 expression with malignant transformation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.