ArticleSchizophrenia research2011
Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes.
Article in Schizophrenia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials.International journal of molecular sciences · 2024Review
- Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model.Molecular psychiatry · 2022Article
- Astrocyte Bioenergetics and Major Psychiatric Disorders.Advances in neurobiology · 2021Review
- Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia.Frontiers in psychiatry · 2020Review
- Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.Molecular psychiatry · 2019Article
- Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.Molecular psychiatry · 2018Article
- Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.Schizophrenia bulletin · 2018Article
- DISC1 Regulates the Proliferation and Migration of Mouse Neural Stem/Progenitor Cells through Pax5, Sox2, Dll1 and Neurog2.Frontiers in cellular neuroscience · 2017Article
- Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.European archives of psychiatry and clinical neuroscience · 2016Article
- Utility and validity of DISC1 mouse models in biological psychiatry.Neuroscience · 2016Review
- Cell Type-Specific Effects of Mutant DISC1: A Proteomics Study.Molecular neuropsychiatry · 2016Article
- Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness.Biology open · 2015Article
- A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue.Frontiers in cellular neuroscience · 2015Review
- Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.BioMed research international · 2015Review
- Potential primary roles of glial cells in the mechanisms of psychiatric disorders.Frontiers in cellular neuroscience · 2015Review
- Advancements in the Underlying Pathogenesis of Schizophrenia: Implications of DNA Methylation in Glial Cells.Frontiers in cellular neuroscience · 2015Review
- Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.The European journal of neuroscience · 2014Review
- Article
- Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities.Frontiers in cellular neuroscience · 2014Review
- Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control.Translational psychiatry · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Abnormalities in oligodendrocyte (OLG) differentiation and OLG gene expression deficit have been described in schizophrenia (SZ). Recent studies revealed a critical requirement for Disrupted-in-Schizophrenia 1 (DISC1) in neural development. Transgenic mice with forebrain restricted expression of mutant human DISC1 (ΔhDISC1) are characterized by neuroanatomical and behavioral abnormalities reminiscent of some features of SZ. We sought to determine whether the expression of ΔhDISC1 may influence the development of OLGs in this mouse model. OLG- and cell cycle-associated gene and protein expression were characterized in the forebrain of ΔhDISC1 mice during different stages of neurodevelopment (E15 and P1 days) and in adulthood. The results suggest that the expression of ΔhDISC1 exerts a significant influence on oligodendrocyte differentiation and function, evidenced by premature OLG differentiation and increased proliferation of their progenitors. Additional findings showed that neuregulin 1 and its receptors may be contributing factors to the observed upregulation of OLG genes. Thus, OLG function may be perturbed by mutant hDISC1 in a model system that provides new avenues for studying aspects of the pathogenesis of SZ.
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Registered trials
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