ArticleThe Journal of surgical research2011
Distraction induced enterogenesis: a unique mouse model using polyethylene glycol.
Article in The Journal of surgical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Generation of Porcine Ileum Through Spring-Mediated Mechanical Distraction.The Journal of surgical research · 2022Article
- Self-expanding intestinal expansion sleeves (IES) for short gut syndrome.Pediatric surgery international · 2022Article
- Biomechanical Force Prediction for Lengthening of Small Intestine during Distraction Enterogenesis.Bioengineering (Basel, Switzerland) · 2020Article
- New insights and interventions for short bowel syndrome.Current pediatrics reports · 2017Article
- Development of an endoluminal intestinal attachment for a clinically applicable distraction enterogenesis device.Journal of pediatric surgery · 2016Article
- Development of an endoluminal intestinal lengthening device using a geometric intestinal attachment approach.Surgery · 2015Article
- A novel double-balloon catheter device for fully endoluminal intestinal lengthening.Pediatric surgery international · 2014Article
- Distraction-induced intestinal growth: the role of mechanotransduction mechanisms in a mouse model of short bowel syndrome.Tissue engineering. Part A · 2014Article
- Glucagon-like peptide 2 increases efficacy of distraction enterogenesis.The Journal of surgical research · 2013Article
- Mesenteric neovascularization with distraction-induced intestinal growth: enterogenesis.Pediatric surgery international · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundRecent studies have demonstrated that the small intestine can be lengthened by applying mechanical forces to the bowel lumen-distraction-induced enterogenesis. However, the mechanisms which account for this growth are unknown, and might be best examined using a mouse model. The purpose of this study is to establish the feasibility of developing distractive-induced small bowel growth in mouse.
methodsTwelve-week old C57BL/6J mice had a jejunal segment taken out of continuity, and distended with polyethylene glycol (PEG: 3350 KDa); this group was compared with a control group without stretching. Segment length and diameter were measured intra-operatively and after 5 d. Villus height, crypt depth, and muscle thickness in the isolated segment were assessed. Rate of epithelial cell proliferation (5-bromo-2-deoxyuridine: BrdU incorporation) in crypts were also examined. The mucosal mRNA expression of targeted factors was performed to investigate potential mechanisms which might lead to distraction-induced enterogenesis.
resultsAt harvest, the PEG-stretched group showed a significant increase in length and diameter versus controls. Villus height, crypt depth, and muscular layer thickness increased in the PEG group. The PEG group also showed significantly increased rates of epithelial cell proliferation versus controls. Real-time PCR showed a trend toward higher β-catenin and c-myc mRNA expression in the PEG-stretched group; however, this difference was not statistically significant.
conclusionsRadial distraction-induced enterogenesis with PEG is a viable method for increasing small intestinal length and diameter. This model may provide a new method for studying the mechanisms leading to distraction-induced enterogenesis.
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