ArticleMolecular and cellular biology1990
Transformation by v-myb correlates with trans-activation of gene expression.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability.Oncogene · 2011Article
- A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding.Molecular cancer · 2008Article
- Regulation of the gene encoding glutathione S-transferase M1 (GSTM1) by the Myb oncoprotein.Oncogene · 2003Article
- Two Drosophila Ada2 homologues function in different multiprotein complexes.Molecular and cellular biology · 2003Article
- Identification and characterization of the Myb-inducible promoter of the chicken adenosine receptor 2B gene.Oncogene · 2002Article
- Article
- Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression.Nucleic acids research · 2001Article
- The chicken Pdcd4 gene is regulated by v-Myb.Oncogene · 2001Article
- BS69, an adenovirus E1A-associated protein, inhibits the transcriptional activity of c-Myb.Oncogene · 2001Article
- Functional analysis of carboxy-terminal deletion mutants of c-Myb.Journal of virology · 1999Article
- Transcriptional regulation by the carboxyl terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site.Oncogene · 1999Article
- Review
- Transformation by v-Myb.Oncogene · 1999Review
- Overexpression of an alternatively spliced form of c-Myb results in increases in transactivation and transforms avian myelomonoblasts.Journal of virology · 1998Article
- Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.Molecular and cellular biology · 1998Article
- Ectopic expression of A-myb in transgenic mice causes follicular hyperplasia and enhanced B lymphocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cells.The EMBO journal · 1997Article
- FAETL motif required for leukemic transformation by v-Myb.Journal of virology · 1996Article
- Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.Molecular and cellular biology · 1996Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The v-myb oncogene of avian myeloblastosis virus causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its protein product p48v-myb is a nuclear, sequence-specific, DNA-binding protein which activates gene expression in transient DNA transfection studies. To investigate the relationship between transformation and trans-activation by v-myb, we constructed 15 in-frame linker insertion mutants. The 12 mutants which transformed myeloid cells also trans-activated gene expression, whereas the 3 mutants which did not transform also did not trans-activate. This implies that trans-activation is required for transformation by v-myb. One of the transformation-defective mutants localized to the cell nucleus but failed to bind DNA. The other two transformation-defective mutants localized to the cell nucleus and bound DNA but nevertheless failed to trans-activate. These latter mutants define two distinct domains of p48v-myb which control trans-activation by DNA-bound protein, one within the amino-terminal DNA-binding domain itself and one in a carboxyl-terminal domain which is not required for DNA binding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.