ReviewBiochimica et biophysica acta2011
Intracellular α(2C)-adrenoceptors: storage depot, stunted development or signaling domain?
Review in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- DangGuiSiNi Decoction and QiShenYiQi Pills Ameliorate Hyperpermeability and Edema Induced by Cold Exposure.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Alternate quantification approaches for cold-induced vasodilation in human glabrous skin.Frontiers in physiology · 2025Article
- Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity.Cell genomics · 2024Article
- Inhibiting Intracellular αInternational journal of molecular sciences · 2023Article
- Human Placenta Expresses αThe American journal of pathology · 2018Article
- A vascular mechanistic approach to understanding Raynaud phenomenon.Nature reviews. Rheumatology · 2015Review
- Perspective on the role of the N-terminal tail of the α2C-adrenoceptor.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-αJournal of cytology & molecular biology · 2014Article
- Article
- GPER Function in Breast Cancer: An Overview.Frontiers in endocrinology · 2014Review
- The C-terminal half of the α2C-adrenoceptor determines the receptor's membrane expression level and drug selectivity.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2.American journal of physiology. Cell physiology · 2013Article
- G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth.Obstetrics and gynecology international · 2013Article
- Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.American journal of physiology. Cell physiology · 2012Article
- Alpha2C-adrenoceptors play a prominent role in sympathetic constriction of porcine pulmonary arteries.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell's interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α(2C)-Adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.