ArticleBMC medicine2011
Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?
Article in BMC medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 139 citations in OpenAlex.
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- Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Mitochondrial Signaling Pathways Associated with DNA Damage Responses.International journal of molecular sciences · 2023Review
- The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner.Antioxidants (Basel, Switzerland) · 2023Article
- The Role of the Thioredoxin Detoxification System in Cancer Progression and Resistance.Frontiers in molecular biosciences · 2022Review
- A macrocyclic molecule with multiple antioxidative activities protects the lens from oxidative damage.Frontiers in chemistry · 2022Article
- Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study.Scientific reports · 2021Article
- Physical activity and cancer risk. Actual knowledge and possible biological mechanisms.Radiology and oncology · 2021Review
- Evaluation of Thiol/Disulfide Homeostasis in Lung Cancer.Turkish thoracic journal · 2020Article
- Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives.Diagnostics (Basel, Switzerland) · 2020Article
- Dietary AGEs involvement in colonic inflammation and cancer: insights from an in vitro enterocyte model.Scientific reports · 2020Article
- Breastfeeding predicts blood mitochondrial DNA content in adolescents.Scientific reports · 2020Article
- Oncogenic pathways and the electron transport chain: a dangeROS liaison.British journal of cancer · 2020Review
- Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway.Oxidative medicine and cellular longevity · 2020Article
7 more citing papers are in PubMed but not listed here.
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3 authors at 2 institutions in 1 country.
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Abstract
The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al., directly addresses this issue by using a molecular genetic approach, via an established mouse animal model of human breast cancer. More specifically, alleviation of mitochondrial oxidative stress, via transgenic over-expression of catalase (an anti-oxidant enzyme) targeted to mitochondria, was sufficient to lower tumor grade (from high-to-low) and to dramatically reduce metastatic tumor burden by >12-fold. Here, we discuss these new findings and place them in the context of several other recent studies showing that oxidative stress directly contributes to tumor progression and metastasis. These results have important clinical and translational significance, as most current chemo-therapeutic agents and radiation therapy increase oxidative stress, and, therefore, could help drive tumor recurrence and metastasis. Similarly, chemo- and radiation-therapy both increase the risk for developing a secondary malignancy, such as leukemia and/or lymphoma. To effectively reduce mitochondrial oxidative stress, medical oncologists should now re-consider the use of powerful anti-oxidants as a key component of patient therapy and cancer prevention. Please see related research article: http://www.biomedcentral.com/1471-2407/11/191.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.