ArticleGenes, brain, and behavior2011
Functional dissection of Odorant binding protein genes in Drosophila melanogaster.
Article in Genes, brain, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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102 citing papers in PubMed, 196 citations in OpenAlex.
- Adaptive Evolution of Odorant-Binding and Chemosensory Protein Gene Families in GenusBiomolecules · 2026Article
- Prokaryotic Expression and Binding Characteristics of Odor-Binding Protein GqinOBP10 inInternational journal of molecular sciences · 2025Article
- The Odorant-Binding Proteins AspiOBP1 and AspiOBP2 inInternational journal of molecular sciences · 2025Article
- Characterization of odorant binding and chemosensory protein families in the kissing bug Triatoma infestans: comparative analysis among Heteroptera species.BMC genomics · 2025Article
- Chromosome-level genome assembly of the synanthropic fly Chrysomya megacephala: insights into oviposition location.BMC genomics · 2025Article
- Genome-Wide Identification and Expression Profiling of Odorant-Binding Protein Genes in the Bean Flower ThripsInsects · 2025Article
- Stage-resolved transcriptomic profiling ofFrontiers in insect science · 2025Article
- NMR chemical shift assignment of Drosophila odorant binding protein 44a in complex with 8(Z)-eicosenoic acid.Biomolecular NMR assignments · 2024Article
- Article
- Antennal transcriptome analysis of Psyttalia incisi (silvestri) (Hymenoptera: Braconidae): identification and tissue expression profiling of candidate odorant-binding protein genes.Molecular biology reports · 2024Article
- Identification of candidate chemosensory genes inFrontiers in physiology · 2024Article
- Article
- Activity of Single Insect Olfactory Receptors Triggered by Airborne Compounds Recorded in Self-Assembled Tethered Lipid Bilayer Nanoarchitectures.ACS applied materials & interfaces · 2023Article
- Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response.PLoS genetics · 2023Article
- Characterization and Functional Analysis ofInsects · 2023Article
- Pleiotropic fitness effects of a Drosophila odorant-binding protein.G3 (Bethesda, Md.) · 2023Article
- Roles of insect odorant binding proteins in communication and xenobiotic adaptation.Frontiers in insect science · 2023Review
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Evolutionarily conserved odorant-binding proteins participate in establishing tritrophic interactions.iScience · 2022Article
- Regulation of sensory perception and motor abilities by brain-specific action of chromatin remodeling factor CHD1.Frontiers in molecular neuroscience · 2022Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Most organisms rely on olfaction for survival and reproduction. The olfactory system of Drosophila melanogaster is one of the best characterized chemosensory systems and serves as a prototype for understanding insect olfaction. Olfaction in Drosophila is mediated by multigene families of odorant receptors and odorant binding proteins (OBPs). Although molecular response profiles of odorant receptors have been well documented, the contributions of OBPs to olfactory behavior remain largely unknown. Here, we used RNAi-mediated suppression of Obp gene expression and measurements of behavioral responses to 16 ecologically relevant odorants to systematically dissect the functions of 17 OBPs. We quantified the effectiveness of RNAi-mediated suppression by quantitative real-time polymerase chain reaction and used a proteomic liquid chromatography and tandem mass spectrometry procedure to show target-specific suppression of OBPs expressed in the antennae. Flies in which expression of a specific OBP is suppressed often show altered behavioral responses to more than one, but not all, odorants, in a sex-dependent manner. Similarly, responses to a specific odorant are frequently affected by suppression of expression of multiple, but not all, OBPs. These results show that OBPs are essential for mediating olfactory behavioral responses and suggest that OBP-dependent odorant recognition is combinatorial.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.