ArticleMagnetic resonance in medicine2011
Layer-specific functional and anatomical MRI of the retina with passband balanced SSFP.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Connexin 50 Influences the Physiological Optics of the In Vivo Mouse Lens.Investigative ophthalmology & visual science · 2024Article
- Improved MRI methods to quantify retinal and choroidal blood flow applied to a model of glaucoma.Frontiers in ophthalmology · 2024Article
- Imaging ocular water inflow in the mouse with deuterium oxide MRI.Magnetic resonance imaging · 2023Article
- Age-Dependent Changes in the Water Content and Optical Power of the In Vivo Mouse Lens Revealed by Multi-Parametric MRI and Optical Modeling.Investigative ophthalmology & visual science · 2023Article
- 3T high-resolution magnetic resonance imaging, conventional ultrasonography and ultrasound biomicroscopy of the normal canine eye.BMC veterinary research · 2022Article
- Effects of chronic mild hyperoxia on retinal and choroidal blood flow and retinal function in the DBA/2J mouse model of glaucoma.PloS one · 2022Article
- Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography.Investigative ophthalmology & visual science · 2021Article
- Diabetic mice have retinal and choroidal blood flow deficits and electroretinogram deficits with impaired responses to hypercapnia.PloS one · 2021Article
- Multi-parametric MRI of the physiology and optics of the in-vivo mouse lens.Magnetic resonance imaging · 2020Article
- Functional-Optical Coherence Tomography: A Non-invasive Approach to Assess the Sympathetic Nervous System and Intrinsic Vascular Regulation.Frontiers in physiology · 2019Article
- Dynamic Imaging of the Eye, Optic Nerve, and Extraocular Muscles With Golden Angle Radial MRI.Investigative ophthalmology & visual science · 2017Article
- Layer-Specific Manganese-Enhanced MRI of the Diabetic Rat Retina in Light and Dark Adaptation at 11.7 Tesla.Investigative ophthalmology & visual science · 2015Article
- Cerebral angiography, blood flow and vascular reactivity in progressive hypertension.NeuroImage · 2015Article
- Ultra-high spatial resolution basal and evoked cerebral blood flow MRI of the rat brain.Brain research · 2015Article
- Steady-state functional MRI using spoiled small-tip fast recovery imaging.Magnetic resonance in medicine · 2015Article
- Choroidal blood flow decreases with age: an MRI study.Current eye research · 2014Article
- Manganese-enhanced MRI (MEMRI) via topical loading of Mn(2+) significantly impairs mouse visual acuity: a comparison with intravitreal injection.NMR in biomedicine · 2014Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension.Experimental eye research · 2013Article
- Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The retina consists of multiple cellular and synaptic layers and is nourished by two distinct (retinal and choroidal) circulations bounding the retina, separated by an avascular layer. High spatiotemporal resolution, layer-specific MRI of the retina remains challenging due to magnetic inhomogeneity-induced artifacts. This study reports passband balanced steady-state free-precession (bSSFP) MRI at 45×45×500 μm and 1.6 s temporal resolution to image the mouse retina, overcoming geometric distortion and signal dropout while maintaining rapid acquisition and high signal-to-noise ratio. bSSFP images revealed multiple alternating dark-bright-dark-bright retinal layers. Hypoxic (10% O(2) ) inhalation decreased bSSFP signals in the two layers bounding the retina, corresponding to the retinal and choroidal vasculatures. The layer in between showed no substantial response and was assigned the avascular photoreceptor layers. Choroidal responses (-25.9 ± 6.4%, mean ± SD, n=6) were significantly (P<0.05) larger than retinal vascular responses (-11.6±2.4%). bSSFP offers very high spatiotemporal resolution and could have important applications in imaging layer-specific changes in retinal diseases.
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