ArticleThe European physical journal. E, Soft matter2011
Nonlinear ionic pulses along microtubules.
Article in The European physical journal. E, Soft matter, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 102 citations in OpenAlex.
- Electrical oscillations in microtubules.Scientific reports · 2025Article
- Electrical Oscillations in Microtubules.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases.Nanomaterials (Basel, Switzerland) · 2024Article
- Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis.Cellular and molecular neurobiology · 2023Article
- Role of the microtubules in the electrical activity of the primary cilium of renal epithelial cells.Frontiers in molecular biosciences · 2023Article
- Calcium signal transmission by axonemal microtubules as an optimized information pathway in cilia and flagella.Journal of bioenergetics and biomembranes · 2021Article
- Modeling Microtubule Counterion Distributions and Conductivity Using the Poisson-Boltzmann Equation.Frontiers in molecular biosciences · 2021Article
- Calcium signaling modulates the dynamics of cilia and flagella.European biophysics journal : EBJ · 2020Article
- Investigation of the Electrical Properties of Microtubule Ensembles under Cell-Like Conditions.Nanomaterials (Basel, Switzerland) · 2020Article
- Behavior of α, β tubulin in DMSO-containing electrolytes.Nanoscale advances · 2019Article
- Two-Dimensional Brain Microtubule Structures Behave as Memristive Devices.Scientific reports · 2019Article
- Nanowired Bioelectric Interfaces.Chemical reviews · 2019Review
- Physical energies to the rescue of damaged tissues.World journal of stem cells · 2019Review
- Tubulin Polarizability in Aqueous Suspensions.ACS omega · 2019Article
- On discovering functions in actin filament automata.Royal Society open science · 2019Article
- Bundles of Brain Microtubules Generate Electrical Oscillations.Scientific reports · 2018Article
- Talking to cells: semiconductor nanomaterials at the cellular interface.Advanced biosystems · 2018Article
- Calcium-axonemal microtubuli interactions underlie mechanism(s) of primary cilia morphological changes.Journal of biological physics · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules are cylindrically shaped cytoskeletal biopolymers that are essential for cell motility, cell division and intracellular trafficking. Here, we investigate their polyelectrolyte character that plays a very important role in ionic transport throughout the intra-cellular environment. The model we propose demonstrates an essentially nonlinear behavior of ionic currents which are guided by microtubules. These features are primarily due to the dynamics of tubulin C-terminal tails which are extended out of the surface of the microtubule cylinder. We also demonstrate that the origin of nonlinearity stems from the nonlinear capacitance of each tubulin dimer. This brings about conditions required for the creation and propagation of solitonic ionic waves along the microtubule axis. We conclude that a microtubule plays the role of a biological nonlinear transmission line for ionic currents. These currents might be of particular significance in cell division and possibly also in cognitive processes taking place in nerve cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.