ArticlePediatric nephrology (Berlin, Germany)2011
Urine IL-8 concentrations in infectious and non-infectious urinary tract conditions.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Urinary Tract Infections Detection with Molecular Biomarkers.Biomolecules · 2024Review
- Assessment of urine calprotectin and YKL-40 levels in urinary tract infection diagnosis in children under 2 years of age.Scientific reports · 2024Article
- Biomarkers for febrile urinary tract infection in children.Frontiers in pediatrics · 2023Article
- Biomarkers in urinary tract infections - which ones are suitable for diagnostics and follow-up?GMS infectious diseases · 2020Review
- Urine neutrophil gelatinase-associated lipocalin and other biomarkers in infants with urinary tract infection and in febrile controls.Pediatric nephrology (Berlin, Germany) · 2017Article
- Urinary concentration of cytokines in children with acute pyelonephritis.European journal of pediatrics · 2013Observational
- Urinary excretion of EGF and MCP-1 in children with vesicoureteral reflux.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
6 authors.
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Abstract
Urine IL-8 concentrations are known to be elevated in urinary tract infection (UTI), as well as in vesicoureteral reflux (VUR) even in the absence of infection. In this study we further investigated urine IL-8 in infants with congenital anomalies of the kidneys and urinary tract and with antenatally diagnosed isolated pelvic dilatation. Urine IL-8 was measured in 159 infants aged 1 month to 1 year with acute UTI (group A, n = 26), resolved UTI (group B, n = 16), VUR without recent UTI (group C, n = 44), non-VUR congenital urinary anomalies without recent UTI (group D, n = 30), isolated antenatal pelvic dilatation (group E, n = 14) and in infants without known urinary tract condition (control group F, n = 29). Median values of urine IL-8/creatinine levels were 61.5, 4.64, 15.5, 14.3, 1.06 and 4.19 pg/μmol in groups A, B, C, D, E and F respectively. Compared with the control group, urine IL-8 was elevated in infants with acute UTI, VUR without acute UTI and congenital anomalies without acute UTI (p < 0.0001; p < 0.005; and p = 0.027 respectively), but not in infants with resolved UTI or with antenatal pelvic dilatation. Urine IL-8 levels are elevated in a variety of infectious and non-infectious urinary tract conditions, and hence may serve as a sensitive but not specific screening biomarker of urinary tract diseases.
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