Trial reportPsychopharmacology2011
Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteers.
Trial report in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Gabapentin increases the abuse liability of alcohol alone and in combination with oxycodone in participants with co-occurring opioid and alcohol use disorder.Pharmacology, biochemistry, and behavior · 2022Trial
- Trial
- Self-reported cumulative medical opioid exposure and subjective responses on first use of opioids predict analgesic and subjective responses to placebo-controlled opioid administration.Regional anesthesia and pain medicine · 2019Trial
- Separate and combined psychopharmacological effects of alprazolam and oxycodone in healthy volunteers.Drug and alcohol dependence · 2012Trial
- Subjective, psychomotor, and physiological effects of pregabalin alone and in combination with oxycodone in healthy volunteers.Pharmacology, biochemistry, and behavior · 2012Trial
- Potentiation of fentanyl-induced respiratory depression by alcohol is not fully reversed by naloxone.JCI insight · 2026Article
- Recent advances in alcohol metabolism: from the gut to the brain.Physiological reviews · 2025Review
- Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking.Scientific reports · 2023Article
- Risky alcohol use among patients dispensed opioid medications: A clinical community pharmacy study.Drug and alcohol dependence · 2022Article
- Elevated customary alcohol consumption attenuates opioid effects.Pharmacology, biochemistry, and behavior · 2021Article
- Opioid Use and Driving Performance.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Review
- The role of the opioid system in decision making and cognitive control: A review.Cognitive, affective & behavioral neuroscience · 2019Review
- A Single Amino Acid Residue at Transmembrane Domain 4 of theThe Journal of pharmacology and experimental therapeutics · 2017Article
- Trends in Prescription Opioids Detected in Fatally Injured Drivers in 6 US States: 1995-2015.American journal of public health · 2017Article
- High-intensity drinking and nonmedical use of prescription drugs: Results from a national survey of 12th grade students.Drug and alcohol dependence · 2017Article
- Burden of Alcohol Abuse or Dependence Among Long-Term Opioid Users with Chronic Noncancer Pain.Journal of managed care & specialty pharmacy · 2017Article
- Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol).Clinical pharmacokinetics · 2014Review
- Risks, management, and monitoring of combination opioid, benzodiazepines, and/or alcohol use.Postgraduate medicine · 2013Review
- Co-ingestion of prescription opioids and other drugs among high school seniors: results from a national study.Drug and alcohol dependence · 2012Article
- Use of oxycodone in pain management.Anesthesiology and pain medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleNonmedical use of prescription opioids is sometimes accompanied by the ingestion of ethanol. Whether ethanol increases the abuse liability-related effects of prescription opioids has not been determined.
objectiveThe purpose of this study was to characterize the subjective, psychomotor, and physiological effects of oxycodone, a widely prescribed and abused opioid, and ethanol, alone and in combination.
methodsFourteen volunteers participated in a randomized, crossover trial in which they were exposed to placebo, oxycodone (10 mg), two doses of ethanol (0.3 and 0.6 g/kg), and oxycodone combined with the lower dose and the higher dose of ethanol on separate sessions.
resultsSeveral abuse liability-related subjective effects (drug liking, take again, pleasant bodily sensations) were not increased by the low dose of ethanol or oxycodone alone relative to placebo, but were when the two were combined. Self-reported liking of the higher dose of ethanol was higher than that of placebo, but oxycodone neither increased nor decreased this effect. Psychomotor and cognitive performance was not affected by any of the active drug conditions. Absorption of ethanol was decreased by oxycodone.
conclusionsIn this study, 10 mg of oral oxycodone combined with a low dose of ethanol generated abuse liability-related effects, but when tested separately, they did not. Further psychopharmacological investigations of this combination are warranted in light of these findings and the fact that nonmedical use of prescription opioids is sometimes accompanied by use of ethanol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.