ArticlePloS one2011
The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies.BioMed research international · 2015Pooled it
- Exploring the causal links between inflammation-related genes and atherosclerosis through Mendelian randomization analysis.Medicine · 2025Article
- Pericardial Adipose Tissue Thrombospondin-1 Associates With Antiangiogenesis in Ischemic Heart Disease.The American journal of cardiology · 2024Article
- A Transcriptomic Analysis of Smoking-Induced Gene Expression Alterations in Coronary Artery Disease Patients.International journal of molecular sciences · 2023Article
- T lymphocyte characteristics and immune repertoires in the epicardial adipose tissue of heart failure patients.Frontiers in immunology · 2023Article
- Presence of periodontal pathogenic bacteria in blood of patients with coronary artery disease.Scientific reports · 2022Article
- Serum miRNA Profile in Diabetic Patients With Ischemic Heart Disease as a Promising Non-Invasive Biomarker.Frontiers in endocrinology · 2022Article
- Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease.Journal of inflammation research · 2021Article
- Dysregulation of epicardial adipose tissue in cachexia due to heart failure: the role of natriuretic peptides and cardiolipin.Journal of cachexia, sarcopenia and muscle · 2020Article
- Article
- Epicardial adipose tissue: an emerging biomarker of cardiovascular complications in type 2 diabetes?Therapeutic advances in endocrinology and metabolism · 2020Article
- DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits.Genome biology · 2019Article
- Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat.JCI insight · 2019Observational
- Article
- TMT Based Proteomic Analysis of Human Follicular Fluid From Overweight/Obese and Normal-Weight Patients With Polycystic Ovary Syndrome.Frontiers in endocrinology · 2019Article
- Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches?British journal of pharmacology · 2017Review
- Novel atherogenic pathways from the differential transcriptome analysis of diabetic epicardial adipose tissue.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017Article
- Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease.Scientific reports · 2017Article
- 'Browning' the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk.International journal of cardiology · 2017Review
- RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.Physiological genomics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe biological functions of epicardial adipose tissue (EAT) remain largely unknown. However, the proximity of EAT to the coronary arteries suggests a role in the pathogenesis of coronary artery disease (CAD). The objectives of this study were to identify genes differentially regulated among three adipose tissues, namely EAT, mediastinal (MAT) and subcutaneous (SAT) and to study their possible relationships with the development of cardiovascular diseases. METHODS AND
resultsSamples were collected from subjects undergoing coronary artery bypass grafting surgeries. Gene expression was evaluated in the three adipose depots of six men using the Illumina® HumanWG-6 v3.0 expression BeadChips. Twenty-three and 73 genes were differentially up-regulated in EAT compared to MAT and SAT, respectively. Ninety-four genes were down-regulated in EAT compared to SAT. However, none were significantly down-regulated in EAT compared to MAT. More specifically, the expression of the adenosine A1 receptor (ADORA1), involved in myocardial ischemia, was significantly up-regulated in EAT. Levels of the prostaglandin D2 synthase (PTGDS) gene, recently associated with the progression of atherosclerosis, were significantly different in the three pairwise comparisons (EAT>MAT>SAT). The results of ADORA1 and PTGDS were confirmed by quantitative real-time PCR in 25 independent subjects.
conclusionsOverall, the transcriptional profiles of EAT and MAT were similar compared to the SAT. Despite this similarity, two genes involved in cardiovascular diseases, ADORA1 and PTGDS, were differentially up-regulated in EAT. These results provide insights about the biology of EAT and its potential implication in CAD.
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