ArticleInternational journal of molecular imaging2011
Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies.
Article in International journal of molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Imaging ofEJNMMI physics · 2023Article
- Assessment of mouse-specific pharmacokinetics in kidneys based onEJNMMI physics · 2022Article
- Preclinical Voxel-Based Dosimetry in Theranostics: a Review.Nuclear medicine and molecular imaging · 2020Review
- Internal radiation dosimetry of aEJNMMI research · 2019Article
- Implementation of absolute quantification in small-animal SPECT imaging: Phantom and animal studies.Journal of applied clinical medical physics · 2017Article
- Pre-clinical quantitative imaging and mouse-specific dosimetry forEJNMMI research · 2016Article
- Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: towards a biomarker of neurologic deficits.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Performance evaluation of stationary and semi-stationary acquisition with a non-stationary small animal multi-pinhole SPECT system.Molecular imaging and biology · 2014Article
- Quantitative liver lesion volume determination by nanoparticle-based SPECT.Molecular imaging and biology · 2014Article
- Antitumor effects ofOncology letters · 2013Article
- Systematic evaluation of 99mTc-tetrofosmin versus 99mTc-sestamibi to study murine myocardial perfusion in small animal SPECT/CT.EJNMMI research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the accuracy of a single photon emission computed tomography (SPECT) system in quantifying a wide range of radioactivity concentrations using different scan times in both phantom and animal models. A phantom containing various amounts of In-111 or Tc-99m was imaged until the activity had decayed close to background levels. Scans were acquired for different durations, employing different collimator pinhole sizes. VOI analysis was performed to quantify uptake in the images and the values compared to the true activity. The phantom results were then validated in tumour-bearing mice. The use of an appropriate calibration phantom and disabling of a background subtraction feature meant that absolute errors were within 12% of the true activity. Furthermore, a comparison of in vivo imaging and biodistribution studies in mice showed a correlation of 0.99 for activities over the 200 kBq to 5 MBq range. We conclude that the quantitative information provided by the NanoSPECT camera is accurate and allows replacement of dissection studies for assessment of radiotracer biodistribution in mouse models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.