ArticleJournal of neurogastroenterology and motility2011
Yield of combined impedance-pH monitoring for refractory reflux symptoms in clinical practice.
Article in Journal of neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Latin American consensus on diagnosis of gastroesophageal reflux disease.Neurogastroenterology and motility · 2024Article
- Extended Wireless pH Monitoring Significantly Increases Gastroesophageal Reflux Disease Diagnoses in Patients With a Normal pH Impedance Study.Journal of neurogastroenterology and motility · 2023Article
- Reflux definitions in esophageal multi-channel intraluminal impedance.Gastroenterology and hepatology from bed to bench · 2023Article
- Multichannel Intraluminal Impedance and pH Monitoring are Complementary Methods in the Diagnosis of Gastroesophageal Reflux Disease in Children.The Eurasian journal of medicine · 2022Article
- Juice Test for Identification of Nonerosive Reflux Disease in Heartburn Patients.Journal of neurogastroenterology and motility · 2018Article
- Management of refractory typical GERD symptoms.Nature reviews. Gastroenterology & hepatology · 2016Review
- Multichannel intraluminal impedance-pH testing is clinically useful in the management of patients with gastroesophageal reflux symptoms.Digestive diseases and sciences · 2014Article
- Acid-based parameters on pH-impedance testing predict symptom improvement with medical management better than impedance parameters.The American journal of gastroenterology · 2014Article
- Prucalopride reduces the number of reflux episodes and improves subjective symptoms in gastroesophageal reflux disease: a case series.Journal of medical case reports · 2014Article
- The value of early wireless esophageal pH monitoring in diagnosing functional heartburn in refractory gastroesophageal reflux disease.Digestive diseases and sciences · 2013Article
- Findings of impedance pH-monitoring in patients with atypical gastroesophageal reflux symptoms.Gastroenterology and hepatology from bed to bench · 2013Article
- Patients with refractory gastroesophageal reflux disease: diagnostic tools.Annals of gastroenterology · 2013Review
- Clinical characteristics in patients with non-cardiac chest pain could favor gastroesophageal reflux disease diagnosis.Annals of gastroenterology · 2013Article
- How Useful the Combined Impedance-pH Monitoring Is for Evaluation of Refractory Reflux Symptoms?Journal of neurogastroenterology and motility · 2011Article
- How Useful the Combined Impedance-pH Monitoring Is for Evaluation of Refractory Reflux Symptoms?: Author's Reply.Journal of neurogastroenterology and motility · 2011Article
- [Latin American Consensus on the Diagnosis of Gastroesophageal Reflux Disease].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsIn patients with gastroesophageal reflux disease, persistent symptoms on proton pump inhibitor (PPI) therapy may be due to residual acid or non-acid reflux. Combined impedance-pH has been suggested to be superior to pH alone in the management of refractory patients to PPI. The utility of implementation of this technique in every day clinical practice is still unknown. The aim of this study was to investigate the outcomes of patients studied with combined impedance-pH and to evaluate the yield of additional impedance monitoring over pH alone in patients with persistent gastroesophageal reflux disease symptoms.
methodsSeventy-one patients (31 men; mean age, 49.1 ± 15.5 years) on PPI therapy underwent combined impedance-pH for persistent typical (76%) or atypical (49%) symptoms.
resultsDuring impedance-pH study, 44 (62%) patients reported symptoms. A positive symptom index (SI) was found in 21 (48%) patients: 8 (18.2%) had a positive SI for acid reflux, 9 (20.5%) for non-acid reflux and 4 (9.1%) for mixed reflux. Addition of impedance allowed association between reflux and symptoms in 20.5% of patients who would have been missed by pH study alone. Heartburn was the most prevalent symptom associated with acid reflux, whereas regurgitation and ear, nose and throat symptoms were associated with non-acid reflux.
conclusionsThe use of combined impedance-pH monitoring substantially increased the diagnostic yield compared to pH alone. With SI analysis, 20.5% of patients received a diagnosis that could not have been achieved with pH testing alone.
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