ArticleJournal of neurogastroenterology and motility2011
Nocturnal gastroesophageal reflux revisited by impedance-pH monitoring.
Article in Journal of neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Pepsin in saliva for the diagnosis of erosive esophagitis post-sleeve gastrectomy: a prospective observational study.Surgical endoscopy · 2023Observational
- Causal analysis between gastro-oesophageal reflux disease and obstructive sleep apnoea.ERJ open research · 2023Article
- Analysis of Esophageal Motility and Reflux Characteristics in Patients with Gastroesophageal Reflux Disease With or Without Extraesophageal Symptoms.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Post-reflux swallow-induced peristaltic wave (PSPW): physiology, triggering factors and role in reflux clearance in healthy subjects.Journal of gastroenterology · 2020Article
- Hiatal hernia predisposes to nocturnal gastro-oesophageal reflux.United European gastroenterology journal · 2013Article
- Role of non-acid reflux in patients with non-erosive reflux disease.Annals of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
aimsImpedance-pH monitoring allows detailed characterization of gastroesophageal reflux and esophageal activity associated with reflux. We assessed the characteristics of nocturnal reflux and esophageal activity preceding and following reflux.
methodsImpedance-pH tracings from 11 healthy subjects and 76 patients with gastroesophageal reflux disease off acid-suppressive therapy were analyzed. Characteristics of nocturnal supine reflux, time distribution and esophageal activity seen on impedance at 2 minute intervals preceding and following reflux were described.
resultsPatients had more nocturnal reflux events than healthy subjects (8 [4-12] vs 2 [1-5], P = 0.002), with lower proportion of weakly acidic reflux (57% [35-78] vs 80% [60-100], P = 0.044). Nocturnal reflux was mainly liquid (80%) and reached the proximal esophagus more often in patients (6% vs 0%, P = 0.047). Acid reflux predominated in the first 2 hours (66%) and weakly acidic reflux in the last 3 hours (70%) of the night. Most nocturnal reflux was preceded by aboral flows and cleared by short lasting volume clearance. In patients, prolonged chemical clearance was associated with less esophageal activity.
conclusionsNocturnal weakly acidic reflux is as common as acid reflux in patients with gastroesophageal reflux disease, and predominates later in the night. Impedance-pH can predict prolonged chemical clearance after nocturnal acid reflux.
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Registered trials
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