ArticleFrontiers in neuroenergetics2011
Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices.
Article in Frontiers in neuroenergetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Relationship Between Peripheral Serum Adiponectin and Cerebrospinal Fluid TNF-α, IL-1β, Lactic Acid, Pyruvic Acid and Perioperative Neurocognitive Dysfunction in Elderly Patients Undergoing Hip Arthroplasty.Clinical interventions in aging · 2025Observational
- Analysis of the Effects of Pentose Phosphate Pathway Inhibition on the Generation of Reactive Oxygen Species and Epileptiform Activity in Hippocampal Slices.International journal of molecular sciences · 2024Article
- Article
- Mitochondrial bioenergetic is impaired in Monocarboxylate transporter 1 deficiency: a new clinical case and review of the literature.Orphanet journal of rare diseases · 2022Review
- Simultaneous Monitoring of pH and Chloride (ClInternational journal of molecular sciences · 2021Article
- Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity.eLife · 2021Article
- Energy metabolism in childhood neurodevelopmental disorders.EBioMedicine · 2021Review
- The distribution and density of monocarboxylate transporter 2 in cerebral cortex, hippocampus and cerebellum of wild-type mice.Journal of anatomy · 2020Article
- Residual feed intake in beef cattle and its association with carcass traits, ruminal solid-fraction bacteria, and epithelium gene expression.Journal of animal science and biotechnology · 2018Article
- Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex.International journal of molecular sciences · 2017Article
- Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.Scientific reports · 2017Article
- Differential Presynaptic ATP Supply for Basal and High-Demand Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sex differences in endogenous cortical network activity: spontaneously recurring Up/Down states.Biology of sex differences · 2017Article
- Article
- Reality of Inhibitory GABA in Neonatal Brain: Time to Rewrite the Textbooks?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Energy and Potassium Ion Homeostasis during Gamma Oscillations.Frontiers in molecular neuroscience · 2016Review
- Examination of the molecular control of ruminal epithelial function in response to dietary restriction and subsequent compensatory growth in cattle.Journal of animal science and biotechnology · 2016Article
- Commentary: Targeting LDH enzymes with a stiripentol analog to treat epilepsy.Frontiers in cellular neuroscience · 2015Article
- Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Energy substrates that fuel fast neuronal network oscillations.Frontiers in neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although numerous experimental data indicate that lactate is efficiently used for energy by the mature brain, the direct measurements of energy metabolism parameters during neuronal network activity in early postnatal development have not been performed. Therefore, the role of lactate in the energy metabolism of neurons at this age remains unclear. In this study, we monitored field potentials and contents of oxygen and NAD(P)H in correlation with oxidative metabolism during intense network activity in the CA1 hippocampal region of neonatal brain slices. We show that in the presence of glucose, lactate is effectively utilized as an energy substrate, causing an augmentation of oxidative metabolism. Moreover, in the absence of glucose lactate is fully capable of maintaining synaptic function. Therefore, during network activity in neonatal slices, lactate can be an efficient energy substrate capable of sustaining and enhancing aerobic energy metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.