Evidence map›Paper›PMID 21602905›Full record

ReviewNature reviews. Molecular cell biology2011

Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis.

Thomas Braun, Mathias Gautel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 394 papers.

0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

394 citing papers in PubMed, 735 citations in OpenAlex.

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  10. A causal SNP in the promoter ofZoological research · 2026
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  17. CD47 Promotes, While Exposure to Apoptotic Cells Destroys the Fusion Program of Differentiating Myoblasts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  18. Article
  19. Review
  20. Article

334 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Thomas BraunMax-Planck-Institute for Heart and Lung Research, Department for Cardiac Development and Remodelling, Benekestrasse, Bad Nauheim, Germany. thomas.braun@ mpi-bn.mpg.de
Mathias Gautel
King's College London · GBMax Planck Society · DE

Funding

Medical Research Council G0200496Medical Research Council G0600251
6 · The paper itself

Abstract

Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas embryonic muscle grows by the proliferation of myogenic cells. Recently, the genetic hierarchies of the myogenic transcription factors that control vertebrate muscle development - by myoblast proliferation, migration, fusion and functional adaptation into fast-twitch and slow-twitch fibres - have become clearer. The transcriptional mechanisms controlling postnatal hypertrophic growth, remodelling and functional differentiation redeploy myogenic factors in concert with serum response factor (SRF), JUNB and forkhead box protein O3A (FOXO3A). It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling.

Indexed as

Muscle, SkeletalTranscription, GeneticAnimalsCell DifferentiationCell ProliferationForkhead Box Protein O3Forkhead Transcription FactorsHomeostasisHumansMicroRNAsMuscle DevelopmentOncogene Protein p65(gag-jun)Protein Processing, Post-TranslationalSerum Response FactorForkhead Box Protein O3Forkhead Transcription FactorsFOXO3 protein, humanMicroRNAsOncogene Protein p65(gag-jun)Serum Response Factor

Identifiers

PMID21602905
OpenAlexW2043251964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.