ArticleOncogene2011
IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.
Article in Oncogene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- IRX1 suppresses breast cancer progression by inhibiting fatty acid de novo synthesis through downregulating ACACA expression.Cell death & disease · 2026Article
- BUB1-based risk model predicts prostate cancer prognosis and reveals therapeutic vulnerabilities.European journal of medical research · 2025Article
- Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma.Cancer metastasis reviews · 2025Review
- Review
- Variation of DNA methylation on theRegenerative therapy · 2022Article
- Analysis of different adipose depot gene expression in cachectic patients with gastric cancer.Nutrition & metabolism · 2022Article
- The Bdkrb2 gene family provides a novel view of viviparity adaptation in Sebastes schlegelii.BMC ecology and evolution · 2021Article
- Article
- Hormonal modulation of ESR1 mutant metastasis.Oncogene · 2021Article
- Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.International journal of biological sciences · 2021Article
- Development and Validation of a Six-Gene Prognostic Signature for Bladder Cancer.Frontiers in genetics · 2021Article
- Comprehensive analysis of prognosis-related methylated sites in breast carcinoma.Molecular genetics & genomic medicine · 2020Article
- Regulation of fibroblast-like synoviocyte transformation by transcription factors in arthritic diseases.Biochemical pharmacology · 2019Review
- Morphological characteristics of vasculogenic mimicry and its correlation with EphA2 expression in gastric adenocarcinoma.Scientific reports · 2019Article
- Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry?Frontiers in oncology · 2019Article
- The Pattern of Signatures in Gastric Cancer Prognosis.International journal of molecular sciences · 2018Review
- Adipocytes fuel gastric cancer omental metastasisTheranostics · 2018Article
- HIF-2α promotes the formation of vasculogenic mimicry in pancreatic cancer by regulating the binding of Twist1 to the VE-cadherin promoter.Oncotarget · 2017Article
- HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma.Scientific reports · 2017Article
- Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer.Oncotarget · 2017Article
Corrections and comments
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The overexpression of IRX1 gene correlates with the growth arrest in gastric cancer. Furthermore, overexpression of IRX1 gene suppresses peritoneal spreading and long distance metastasis. To explore the precise mechanisms, we investigated whether restoring IRX1 expression affects the angiogenesis or vasculogenic mimicry (VM). Human umbilical vein endothelial cells (HUVECs) and chick embryo and SGC-7901 gastric cancer cells were used for angiogenesis and VM analysis. Small interfering RNA was used for analyzing the function of BDKRB2, a downstream target gene of IRX1. As results, the remarkable suppression on peritoneal spreading and pulmonary metastasis of SGC-7901 cells by IRX1 transfectant correlates to reduced angiogenesis as well as VM formation. Using the supernatant from SGC-7901/IRX1 cells, we found a strong inhibiting effect on angiogenesis both in vitro and in chick embryo. SGC-7901/IRX1 cells revealed strong inhibiting effect on VM formation too. By gene-specific RNA interference for BDKRB2, or its effector PAK1, we got an effective inhibition on tube formation, cell proliferation, cell migration and invasion in vitro. In conclusion, enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion. BDKRB2 and its downstream effector might be potential targets for anti-cancer strategy.
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