ArticleThe Journal of antimicrobial chemotherapy2011
Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models.
Article in The Journal of antimicrobial chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Mycobacterial Genetic Technologies for Probing the Host-Pathogen Microenvironment.Infection and immunity · 2023Review
- IL-10 Modulation Increases Pyrazinamide's Antimycobacterial Efficacy against Mycobacterium tuberculosis Infection in Mice.ImmunoHorizons · 2023Article
- One Size Fits All? Not inFrontiers in cellular and infection microbiology · 2021Review
- Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy.Microbiome · 2017Article
- Delamanid Kills Dormant MycobacteriaAntimicrobial agents and chemotherapy · 2017Article
- Preclinical Efficacy Testing of New Drug Candidates.Microbiology spectrum · 2017Review
- De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells Formed against Antituberculosis Drugs In Vitro.Antimicrobial agents and chemotherapy · 2017Article
- Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen.ACS infectious diseases · 2016Article
- New insights into TB physiology suggest untapped therapeutic opportunities.Immunological reviews · 2015Review
- Simvastatin increases the in vivo activity of the first-line tuberculosis regimen.The Journal of antimicrobial chemotherapy · 2014Article
- Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen.Antimicrobial agents and chemotherapy · 2013Article
- Kinetics of IFN-gamma and TNF-alpha gene expression and their relationship with disease progression after infection with Mycobacterium tuberculosis in guinea pigs.Yonsei medical journal · 2013Article
- Vaccination with recombinant Mycobacterium tuberculosis PknD attenuates bacterial dissemination to the brain in guinea pigs.PloS one · 2013Article
- Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigs.Antimicrobial agents and chemotherapy · 2012Article
- Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis.Antimicrobial agents and chemotherapy · 2012Article
- Article
- Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesIt is widely believed that persistent Mycobacterium tuberculosis inhabits necrotic lung granulomas in humans and that the microenvironmental conditions encountered therein render the bacilli phenotypically tolerant to antibiotics, accounting for the long duration required for successful treatment of tuberculosis (TB). To validate this belief, we directly compared the activity of rifampicin/isoniazid/pyrazinamide (RHZ) against chronic TB infection in guinea pigs, which exhibit caseous granulomas histologically resembling human caseous foci, and in mice, which lack necrotic granulomas.
methodsGuinea pigs and mice were aerosol-infected with M. tuberculosis CDC1551 and twice weekly treatment with RHZ was started 4 weeks later. Culture-positive relapse was assessed in subgroups of guinea pigs after 3 months and 4 months of treatment.
resultsAll guinea pig lungs exhibited histological evidence of granulomas with central caseation, while mouse lungs exhibited cellular lesions at the initiation of antibiotic treatment. Guinea pig lungs became culture-negative after 2 months of RHZ given twice weekly at human-equivalent doses. Relapse rates in guinea pigs were 0% (0/10) both after 3 months and 4 months of treatment. In contrast, all mouse lungs remained culture-positive after 4 months of equivalent RHZ exposures.
conclusionsCaseous necrosis does not reduce the sterilizing activity of the standard antituberculosis regimen of RHZ. Our findings have important implications for the use of alternative animal models in testing novel TB drug regimens and for modelling M. tuberculosis persistence.
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