ArticleEukaryotic cell2011
Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of human immunoglobulins onmBio · 2026Article
- Current Insights intoJournal of fungi (Basel, Switzerland) · 2025Article
- Evolutionary uniqueeLife · 2025Article
- The Combination of Iron and Copper Increases Pathogenicity and Induces Proteins Related to the Main Virulence Factors in Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2022Article
- Glucan Unmasking Identifies Regulators of Temperature-Induced Translatome Reprogramming in C. neoformans.mSphere · 2021Article
- Dnj1 Promotes Virulence inFrontiers in microbiology · 2021Article
- Article
- Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming.Nature communications · 2019Article
- Article
- Puf4 regulates both splicing and decay of HXL1 mRNA encoding the unfolded protein response transcription factor in Cryptococcus neoformans.Eukaryotic cell · 2015Article
- Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating.Fungal genetics and biology : FG & B · 2014Article
- Endoplasmic reticulum stress and fungal pathogenesis.Fungal biology reviews · 2014Article
- The unfolded protein response (UPR) pathway in Cryptococcus.Virulence · 2014Review
- The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans.Virulence · 2014Review
- The fungal UPR: a regulatory hub for virulence traits in the mold pathogen Aspergillus fumigatus.Virulence · 2014Review
- Stress signaling pathways for the pathogenicity of Cryptococcus.Eukaryotic cell · 2013Review
- Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans.Molecular microbiology · 2013Article
- The cellular roles of Ccr4-NOT in model and pathogenic fungi-implications for fungal virulence.Frontiers in genetics · 2013Article
- Hydroxyurea enhances post-fusion hyphal extension during sexual development in C. neoformans var. grubii.Mycopathologia · 2012Article
- Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Adaptation to host temperature is a prerequisite for any pathogen capable of causing deep infection in humans. Our previous studies demonstrated that a Cryptococcus neoformans ccr4Δ mutant lacking the major deadenylase involved in regulated mRNA decay was defective in host temperature adaptation and therefore virulence. In this study, the ccr4Δ mutant was found to exhibit characteristics of chronic unfolded-protein response (UPR) engagement in both the gene expression profile and phenotype. We demonstrate that host temperature adaptation in C. neoformans is accompanied by transient induction of the endoplasmic reticulum (ER) stress response and that Ccr4-dependent posttranscriptional gene regulation contributes to resolution of ER stress during host temperature adaptation.
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Registered trials
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