Evidence map›Paper›PMID 21602457›Full record

ArticleThe Journal of clinical endocrinology and metabolism2011

Obesity and type 2 diabetes: what can be unified and what needs to be individualized?

Robert H Eckel, Steven E Kahn, Ele Ferrannini, Allison B Goldfine, David M Nathan, Michael W Schwartz, Robert J Smith, Steven R Smith

2 registry-linked trialsOpen access · bronzeAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 203 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 6 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04268862 unknown statusnot on this mapstarted 2020, after this paper: background citation

Ethnic Dependence of the Metabolic Defects in Prediabetic Individuals: Kuwaiti Arabs Versus Indians

TypeobservationalSponsorDasman Diabetes InstituteRan2020 to 2021Enrolled120ConditionsPathophysiology, Metabolic Glucose Disorders
NCT04626323 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Open, Randomized, Unicenter Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease

TypeinterventionalSponsorHospital Alemão Oswaldo CruzRan2021 to 2024Enrolled60ConditionsDiabetes Mellitus, Type 2, Kidney Disease, Chronic, Kidney InjuryArmsRoux-en-Y gastric bypass, Best medical treatment
3 · Its place in the literature

Who cites it

203 citing papers in PubMed, 6 syntheses or guidelines pooled it, 549 citations in OpenAlex.

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143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 2 countries.

Robert H EckelDivision of Endocrinology, Metabolism and Diabetes, and Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA. robert.eckel@ucdenver.edu
Steven E Kahn
Ele Ferrannini
Allison B Goldfine
David M Nathan
Michael W Schwartz
Robert J Smith
Steven R Smith
Brown University · USJoslin Diabetes Center · USMassachusetts General Hospital · USTranslational Research Institute for Metabolism and Diabetes · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Pisa · ITUniversity of Washington · USVA Puget Sound Health Care System · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Novel Brain Mechanisms Controlling Glucose HomeostasisR01DK083042 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2008 to 2025
$7.6M
Hypothalamic Inflammation and Energy HomeostasisR01DK090320 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2010 to 2014
$1.8M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK083042NIDDK NIH HHS R01 DK090320
6 · The paper itself

Abstract

objectiveThis report examines what is known about the relationship between obesity and type 2 diabetes and how future research in these areas might be directed to benefit prevention, interventions, and overall patient care. RESEARCH DESIGN AND

methodsAn international working group of 32 experts in the pathophysiology, genetics, clinical trials, and clinical care of obesity and/or type 2 diabetes participated in a conference held on 6-7 January 2011 and cosponsored by The Endocrine Society, the American Diabetes Association, and the European Association for the Study of Diabetes. A writing group comprising eight participants subsequently prepared this summary and recommendations. Participants reviewed and discussed published literature and their own unpublished data.

resultsThe writing group unanimously supported the summary and recommendations as representing the working group's majority or unanimous opinions.

conclusionsThe major questions linking obesity to type 2 diabetes that need to be addressed by combined basic, clinical, and population-based scientific approaches include the following: 1) Why do not all patients with obesity develop type 2 diabetes? 2) Through what mechanisms do obesity and insulin resistance contribute to β-cell decompensation, and if/when obesity prevention ensues, how much reduction in type 2 diabetes incidence will follow? 3) How does the duration of type 2 diabetes relate to the benefits of weight reduction by lifestyle, weight-loss drugs, and/or bariatric surgery on β-cell function and glycemia? 4) What is necessary for regulatory approval of medications and possibly surgical approaches for preventing type 2 diabetes in patients with obesity? Improved understanding of how obesity relates to type 2 diabetes may help advance effective and cost-effective interventions for both conditions, including more tailored therapy. To expedite this process, we recommend further investigation into the pathogenesis of these coexistent conditions and innovative approaches to their pharmacological and surgical management.

Indexed as

Diabetes Mellitus, Type 2HumansObesityWeight Loss

Identifiers

PMID21602457
PMCPMC3206399
OpenAlexW2058473208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.