Evidence map›Paper›PMID 21602267›Full record

ArticleNucleic acids research2011

PINTA: a web server for network-based gene prioritization from expression data.

Daniela Nitsch, Léon-Charles Tranchevent, Joana P Gonçalves, Josef Korbinian Vogt, Sara C Madeira, Yves Moreau

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
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  3. Review
  4. Biological Network Mining.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
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  16. Data sources for in vivo molecular profiling of human phenotypes.Wiley interdisciplinary reviews. Systems biology and medicine · 2016
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Daniela NitschDepartment of Electrical Engineering (ESAT-SCD), Katholieke Universiteit Leuven, 3001 Leuven, Belgium.
Léon-Charles Tranchevent
Joana P Gonçalves
Josef Korbinian Vogt
Sara C Madeira
Yves Moreau
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento · PTUniversity of Lisbon · PTKU Leuven · BETechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PINTA (available at http://www.esat.kuleuven.be/pinta/; this web site is free and open to all users and there is no login requirement) is a web resource for the prioritization of candidate genes based on the differential expression of their neighborhood in a genome-wide protein-protein interaction network. Our strategy is meant for biological and medical researchers aiming at identifying novel disease genes using disease specific expression data. PINTA supports both candidate gene prioritization (starting from a user defined set of candidate genes) as well as genome-wide gene prioritization and is available for five species (human, mouse, rat, worm and yeast). As input data, PINTA only requires disease specific expression data, whereas various platforms (e.g. Affymetrix) are supported. As a result, PINTA computes a gene ranking and presents the results as a table that can easily be browsed and downloaded by the user.

Indexed as

Gene Expression ProfilingProtein Interaction MappingSoftwareAnimalsDiseaseGenesHumansInternetMiceRats

Identifiers

PMID21602267
PMCPMC3125740
OpenAlexW2160198684

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.