ArticleMicrobiology (Reading, England)2011
Helicobacter pylori perceives the quorum-sensing molecule AI-2 as a chemorepellent via the chemoreceptor TlpB.
Article in Microbiology (Reading, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 125 citations in OpenAlex.
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- Low pH amplifies chemotaxis toward urea in Helicobacter pylori.Biophysical journal · 2025Article
- Genetic Basis of Gap Formation Between MigratingMicroorganisms · 2025Article
- Autoinducer-2 enhances the defense ofmBio · 2025Article
- Autoinducer-2-mediated communication network within human gut microbiota.The ISME journal · 2025Article
- Regulatory mechanisms of acetic acid, ethanol and high temperature tolerances of acetic acid bacteria during vinegar production.Microbial cell factories · 2024Review
- Helicobacter pylori biofilm interference by N-acyl homoserine lactonases: in vitro and in silico approaches.Molecular biology reports · 2024Article
- Optimization ofInternational journal of molecular sciences · 2024Article
- Deciphering Bacterial Chemorepulsion: The Complex Response of Microbes to Environmental Stimuli.Microorganisms · 2024Review
- Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration inAnnual review of chemical and biomolecular engineering · 2024Review
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- Negative chemotaxis of Ligilactobacillus agilis BKN88 against gut-derived substances.Scientific reports · 2023Article
- Biofilm ofAntibiotics (Basel, Switzerland) · 2023Review
- The Role of Adhesion in Helicobacter pylori Persistent Colonization.Current microbiology · 2023Review
- Helicobacter pylori Chronic-Stage Inflammation Undergoes Fluctuations That Are Altered inInfection and immunity · 2023Article
- Transcriptome Analysis of the Response of MatureAntibiotics (Basel, Switzerland) · 2022Article
- Root exudates and chemotactic strains mediate bacterial community assembly in the rhizosphere soil ofFrontiers in plant science · 2022Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Helicobacter pylori moves in response to environmental chemical cues using a chemotaxis two-component signal-transduction system. Autoinducer-2 (AI-2) is a quorum-sensing signal produced by the LuxS protein that accumulates in the bacterial environment in a density-dependent manner. We showed previously that a H. pylori luxS mutant was defective in motility on soft agar plates. Here we report that deletion of the luxS gene resulted in swimming behaviour with a reduced frequency of stops as compared to the wild-type strain. Stopping frequency was restored to wild-type levels by genetic complementation of the luxS mutation or by addition of synthetic 4,5-dihydroxy-2,3-pentanedione (DPD), which cyclizes to form AI-2. Synthetic DPD also increased the frequency of stops in wild-type H. pylori, similar to the behaviour induced by the known chemorepellent HCl. We found that whereas mutants lacking the chemoreceptor genes tlpA, tlpC or tlpD responded to an exogenous source of synthetic DPD, the chemoreceptor mutant tlpB was non-responsive to a gradient or uniform distribution of the chemical. Furthermore, a double mutant lacking both tlpB and luxS exhibited chemotactic behaviour similar to the tlpB single mutant, whereas a double mutant lacking both tlpB and the chemotransduction gene cheA behaved like a nonchemotactic cheA single mutant, supporting the model that tlpB functions in a signalling pathway downstream of luxS and upstream of cheA. We conclude that H. pylori perceives LuxS-produced AI-2 as a chemorepellent via the chemoreceptor TlpB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.