ArticleNeurobiology of aging2011
Genetic players in multiple system atrophy: unfolding the nature of the beast.
Article in Neurobiology of aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Chromosome X-wide association study in multiple system atrophy identifies sex-differential risk loci.Brain : a journal of neurology · 2026Article
- Rapidly progressive multiple system atrophy in a patient carrying LRRK2 G2019S mutation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad.Molecular neurodegeneration · 2022Review
- Family History for Neurodegeneration in Multiple System Atrophy: Does it Indicate Susceptibility?Movement disorders : official journal of the Movement Disorder Society · 2022Article
- A multiplex pedigree with pathologically confirmed multiple system atrophy and Parkinson's disease with dementia.Brain communications · 2022Article
- The Genetic Landscape of Parkinsonism-Related Dystonias and Atypical Parkinsonism-Related Syndromes.International journal of molecular sciences · 2021Review
- α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?Biomolecules · 2021Review
- Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain.Frontiers in neuroscience · 2019Article
- Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases.Cold Spring Harbor perspectives in biology · 2018Review
- Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1.Journal of Alzheimer's disease : JAD · 2018Review
- Multiple system atrophy: experimental models and reality.Acta neuropathologica · 2018Review
- Large-scale mitochondrial DNA deletion underlying familial multiple system atrophy of the cerebellar subtype.Clinical case reports · 2016Article
- Genetics Underlying Atypical Parkinsonism and Related Neurodegenerative Disorders.International journal of molecular sciences · 2015Review
- Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Review
- Towards translational therapies for multiple system atrophy.Progress in neurobiology · 2014Review
- Lipid dysfunction and pathogenesis of multiple system atrophy.Acta neuropathologica communications · 2014Review
- SHC2 gene copy number in multiple system atrophy (MSA).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Article
- Alpha-synuclein biology in Lewy body diseases.Alzheimer's research & therapy · 2014Review
- Young-onset dementia.Seminars in neurology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Multiple system atrophy (MSA) is a fatal oligodendrogliopathy characterized by prominent α-synuclein inclusions resulting in a neuronal multisystem degeneration. Until recently MSA was widely conceived as a nongenetic disorder. However, during the last years a few postmortem verified Mendelian pedigrees have been reported consistent with monogenic disease in rare cases of MSA. Further, within the last 2 decades several genes have been associated with an increased risk of MSA, first and foremost the SNCA gene coding for α-synuclein. Moreover, genes involved in oxidative stress, mitochondrial dysfunction, inflammatory processes, as well as parkinsonism- and ataxia-related genes have been implicated as susceptibility factors. In this review, we discuss the emerging evidence in favor of genetic players in MSA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.