ArticleJournal of molecular biology2011
Escherichia coli Fpg glycosylase is nonrendundant and required for the rapid global repair of oxidized purine and pyrimidine damage in vivo.
Article in Journal of molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
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- Interspecific differences in oxidative DNA damage after hydrogen peroxide exposure of sea urchin coelomocytes.Mutagenesis · 2023Article
- Escherichia coli induces DNA repair enzymes to protect itself from low-grade hydrogen peroxide stress.Molecular microbiology · 2022Article
- Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.Archives of toxicology · 2022Article
- Events associated with DNA replication disruption are not observed in hydrogen peroxide-treated Escherichia coli.G3 (Bethesda, Md.) · 2021Article
- Manganese Is Required for the Rapid Recovery of DNA Synthesis following Oxidative Challenge inJournal of bacteriology · 2019Article
- Evaluation of oxidative stress responses in human circulating blood cells after imatinib mesylate treatment - Implications to its mechanism of action.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Label-Free Proteomic Approach to Study the Non-lethal Effects of Silver Nanoparticles on a Gut Bacterium.Frontiers in microbiology · 2019Article
- Replication Rapidly Recovers and Continues in the Presence of Hydroxyurea in Escherichia coli.Journal of bacteriology · 2018Article
- UvrA expression ofJournal of food science and technology · 2017Article
- Futile cycling increases sensitivity toward oxidative stress in Escherichia coli.Metabolic engineering · 2015Article
- Oxidative DNA damage is instrumental in hyperreplication stress-induced inviability of Escherichia coli.Nucleic acids research · 2014Article
- Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.Nucleic acids research · 2014Article
- Mfd is required for rapid recovery of transcription following UV-induced DNA damage but not oxidative DNA damage in Escherichia coli.Journal of bacteriology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Endonuclease (Endo) III and formamidopyrimidine-N-glycosylase (Fpg) are two of the predominant DNA glycosylases in Escherichia coli that remove oxidative base damage. In cell extracts and purified form, Endo III is generally more active toward oxidized pyrimidines, while Fpg is more active towards oxidized purines. However, the substrate specificities of these enzymes partially overlap in vitro. Less is known about the relative contribution of these enzymes in restoring the genomic template following oxidative damage. In this study, we examined how efficiently Endo III and Fpg repair their oxidative substrates in vivo following treatment with hydrogen peroxide. We found that Fpg was nonredundant and required to rapidly remove its substrate lesions on the chromosome. In addition, Fpg also repaired a significant portion of the lesions recognized by Endo III, suggesting that it plays a prominent role in the global repair of both purine damage and pyrimidine damage in vivo. By comparison, Endo III did not affect the repair rate of Fpg substrates and was only responsible for repairing a subset of its own substrate lesions in vivo. The absence of Endo VIII or nucleotide excision repair did not significantly affect the global repair of either Fpg or Endo III substrates in vivo. Surprisingly, replication recovered after oxidative DNA damage in all mutants examined, even when lesions persisted in the DNA, suggesting the presence of an efficient mechanism to process or overcome oxidative damage encountered during replication.
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