ArticlePsychoneuroendocrinology2011
Poorer self-rated health is associated with elevated inflammatory markers among older adults.
Article in Psychoneuroendocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
106 citing papers in PubMed, 5 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Self-Rated Health as a Predictor of Mortality in Older Adults: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Pooled it
- Questionnaire and behavioral task measures of impulsivity are differentially associated with body mass index: A comprehensive meta-analysis.Psychological bulletin · 2017Pooled it
- Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation.Biological psychiatry · 2016Pooled it
- Toward patient-centered care: a systematic review of how to ask questions that matter to patients.Medicine · 2014Pooled it
- A perinatal coparenting intervention: Effects of a randomized trial on parent cardiometabolic risk and self-reported health.Biological psychology · 2023Trial
- Self-Rated Health as an Independent Predictor of All-Cause Mortality in Patients With Non-ST-Segment Elevation Myocardial Infarction.Reviews in cardiovascular medicine · 2026Article
- Self-rated health and inflammation: Associations among partnered sexual minority and heterosexual adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Survival After the First Myocardial Infarction in Older Women: A Prospective Cohort Analysis From the WHI.Journal of the American Heart Association · 2026Article
- Salivary and Serum Analytes and Their Associations with Self-rated Health Among Healthy Young Adults.International journal of behavioral medicine · 2026Article
- Review
- Why is income volatility associated with poor health? Longitudinal evidence from the UK and France.SSM - population health · 2025Article
- Healthy lifestyle partly mediates the association between self-rated health and risk of overall and cause-specific mortality.BMC medicine · 2025Article
- Metabolic and Endocrine Alterations in Underweight and Normal-Weight Women with Functional Hypothalamic Amenorrhea.Journal of clinical medicine · 2025Article
- Determinants of depressive symptoms in multinational middle-aged and older adults.NPJ digital medicine · 2025Article
- Associations between dietary diversity and self-rated health in a transverse study of four local food systems (French Guiana, Guadeloupe, Portugal and Senegal).BMC public health · 2025Article
- Determinants of self-rated health in socioeconomically disadvantaged women: a cross-sectional study in Iran.BMC public health · 2025Article
- Self-rated health, epigenetic ageing, and long-term mortality in older Australians.GeroScience · 2024Article
- Sleep and periodontal health.Periodontology 2000 · 2024Review
- Self-reported immune status and COVID-19 associated subjective cognitive functioning in post-COVID-19 syndrome: Examination of an Irish cohort.Brain and behavior · 2024Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveSelf-rated health is a strong independent predictor of mortality after accounting for objective health status, behavioral risk factors, and sociodemographic characteristics. However, mechanisms underlying this association are largely unexplained. Inflammation has been associated with increased risk of morbidity and mortality in the elderly. The current study aimed to: (1) examine associations between self-rated health and serum inflammatory markers in older adults; (2) examine the relative strength of these associations for self-rated health versus self-rated change in recent health; (3) examine components of self-rated health that may underlie the association between inflammation and global self-rated health.
methodsSelf-rated health, as measured by the RAND health survey, and serum interleukin (IL)-6 and C-reactive protein (CRP) were assessed among 250 generally healthy older adults (185 women, 65 men; average age=63.8±13.7 years).
resultsA series of linear regression analyses demonstrated that poorer self-rated health was significantly associated with higher IL-6 and CRP. These relationships remained after controlling for age, body mass index, gender, and objective health conditions. These associations also remained after controlling for depressive symptoms, neuroticism, perceived change in health over the past year, and health behaviors (smoking, sleep quality, and physical activity). Analyses of RAND component measures demonstrated that poorer physical functioning was significantly associated with IL-6; the relationship between global self-rated health and both IL-6 and CRP remained after accounting for perceived physical functioning.
conclusionsPoorer self-rated health is associated with elevated serum inflammatory markers among generally healthy older adults. The relationship of self-rated health with inflammatory markers is not secondary to depressive symptoms, neuroticism, or recent changes in perceived health. Subjective ratings of health provide important clinical information regarding inflammatory status, beyond traditional objective risk factors, even among generally healthy individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.