ArticleJournal of neuroscience methods2011
Sensorimotor behavioral tests for use in a juvenile rat model of traumatic brain injury: assessment of sex differences.
Article in Journal of neuroscience methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Development of a paediatric model of diffuse traumatic brain injury in ferrets.Scientific reports · 2026Article
- Metabolic Diaschisis in Mild Traumatic Brain Injury.Journal of neurotrauma · 2024Article
- Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice.Human molecular genetics · 2024Article
- Gait analysis in swine, sheep, and goats after neurologic injury: a literature review.Neural regeneration research · 2023Review
- Importance of Control Groups for Evaluating Long-Term Behavioral and Cognitive Outcomes of Controlled Cortical Impact in Immature Rats.Journal of neurotrauma · 2023Article
- Neuroscience and actometry: An example of the benefits of the precise measurement of behavior.Brain research bulletin · 2022Review
- Sex specific effects of buprenorphine on behavior, astrocytic opioid receptor expression and neuroinflammation after pediatric traumatic brain injury in mice.Brain, behavior, & immunity - health · 2022Article
- Pediatric Traumatic Brain Injury: An Update on Preclinical Models, Clinical Biomarkers, and the Implications of Cerebrovascular Dysfunction.Journal of central nervous system disease · 2022Review
- Motor Coordination Disorders Evaluated through the Grid Test and Changes in the NigralBehavioral sciences (Basel, Switzerland) · 2020Article
- Sex differences in pediatric traumatic brain injury.Experimental neurology · 2019Review
- Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells.Journal of neurotrauma · 2019Article
- Sex Differences in Animal Models of Traumatic Brain Injury.Journal of experimental neuroscience · 2019Review
- Sex-related responses after traumatic brain injury: Considerations for preclinical modeling.Frontiers in neuroendocrinology · 2018Review
- Rodent Gymnastics: Neurobehavioral Assays in Ischemic Stroke.Molecular neurobiology · 2017Review
- Sex matters: repetitive mild traumatic brain injury in adolescent rats.Annals of clinical and translational neurology · 2017Article
- Progesterone Treatment Shows Benefit in Female Rats in a Pediatric Model of Controlled Cortical Impact Injury.PloS one · 2016Article
- Gait analysis and the cumulative gait index (CGI): Translational tools to assess impairments exhibited by rats with olivocerebellar ataxia.Behavioural brain research · 2014Article
- Progesterone treatment shows benefit in a pediatric model of moderate to severe bilateral brain injury.PloS one · 2014Article
- Fish oil improves motor function, limits blood-brain barrier disruption, and reduces Mmp9 gene expression in a rat model of juvenile traumatic brain injury.Prostaglandins, leukotrienes, and essential fatty acids · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Modeling juvenile traumatic brain injury (TBI) in rodents presents several unique challenges compared to adult TBI, one of which is selecting appropriate sensorimotor behavioral tasks that enable the assessment of the extent of injury and recovery over time in developing animals. To address this challenge, we performed a comparison of common sensorimotor tests in Long-Evans rats of various sizes and developmental stages (postnatal days 16-45, 35-190 g). Tests were compared and selected for their developmental appropriateness, scalability for growth, pre-training requirements, and throughput capability. Sex differences in response to TBI were also assessed. Grid walk, automated gait analysis, rotarod, beam walk, spontaneous forelimb elevation test, and measurement of motor activity using the force-plate actometer were evaluated. Grid walk, gait analysis, and rotarod failed to meet one or more of the evaluation criteria. Beam walk, spontaneous forelimb elevation test, and measurement of motor activity using the force-plate actometer satisfied all criteria and were capable of detecting motor abnormalities in rats subjected to controlled cortical impact on postnatal day 17. No sex differences were detected in the acute effects of TBI or functional recovery during the 28 days after injury using these tests. This demonstrates the utility of these tests for the evaluation of sensorimotor function in studies using rat models of pediatric TBI, and suggests that pre-pubertal males and females respond similarly to TBI with respect to sensorimotor outcomes.
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