Evidence map›Paper›PMID 21600783›Full record

ArticleTrends in endocrinology and metabolism: TEM2011

Pituitary-ovary-spleen axis in ovulation.

Oliver R Oakley, Michele L Frazer, CheMyong Ko

Abstract read
In one paragraph

Article in Trends in endocrinology and metabolism: TEM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Spleen-associated macrophage alterations and embryo viability in a murine model of recurrent spontaneous abortion.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. A single-cell gene expression atlas of human follicular aspirates: Identification of leukocyte subpopulations and their paracrine factors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  6. Review
  7. Endothelin 2: a key player in ovulation and fertility.Reproduction (Cambridge, England) · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Oliver R OakleyDivision of Clinical and Reproductive Sciences, Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, Kentucky 40536, USA.
Michele L Frazer
CheMyong Ko

Funding

Endothelin-2 in Ovarian Follicle RuptureR01HD052694 · NICHD · UNIVERSITY OF KENTUCKY · PI CURRY, THOMAS E · 2006 to 2010
$1.2M
NICHD NIH HHS R01 HD052694NICHD NIH HHS R01HD052694
6 · The paper itself

Abstract

Leukocytes are rapidly recruited to the preovulatory ovary and play a crucial role as facilitators of ovulation and luteal formation. In this article, recent findings on leukocyte trafficking to the ovary, as well as the physiological role of leukocytes in the ovary, will be summarized and discussed. We then explore the novel hypothesis that the hypothalamus-pituitary-ovary (HPO) axis might include the spleen as a reservoir of leukocytes by summarizing recent reports on this topic, both in the fields of immunology and reproductive biology.

Indexed as

FemaleHumansLeukocytesOvaryOvulationPituitary GlandSpleen

Identifiers

PMID21600783
PMCPMC3161174

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.