ArticlePsychoneuroendocrinology2011
Several stressors fail to reduce adult hippocampal neurogenesis.
Article in Psychoneuroendocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans.Molecular psychiatry · 2026Review
- The association of mood disorders and mild cognitive impairment with language performance in older adults: insights from a community healthcare setting.Frontiers in dementia · 2026Article
- Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders.NPJ science of learning · 2022Review
- Stress-Related Dysfunction of Adult Hippocampal Neurogenesis-An Attempt for Understanding Resilience?International journal of molecular sciences · 2021Review
- Review
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives.Neurogenesis (Austin, Tex.) · 2017Article
- Pattern Separation: A Potential Marker of Impaired Hippocampal Adult Neurogenesis in Major Depressive Disorder.Frontiers in neuroscience · 2017Article
- Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes.Stem cells international · 2017Review
- 24-hour-restraint stress induces long-term depressive-like phenotypes in mice.Scientific reports · 2016Article
- Neuronal correlates of depression.Cellular and molecular life sciences : CMLS · 2015Review
- The current state of the neurogenic theory of depression and anxiety.Current opinion in neurobiology · 2015Review
- The Antidepressant-like Effects of Estrogen-mediated Ghrelin.Current neuropharmacology · 2015Review
- Role of adult hippocampal neurogenesis in stress resilience.Neurobiology of stress · 2015Review
- Sex differences in response to chronic mild stress and congenital serotonin deficiency.Psychoneuroendocrinology · 2014Article
- Influence of sex and stress exposure across the lifespan on endophenotypes of depression: focus on behavior, glucocorticoids, and hippocampus.Frontiers in neuroscience · 2014Review
- IFN-γ differentially modulates memory-related processes under basal and chronic stressor conditions.Frontiers in cellular neuroscience · 2014Article
- Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis.Neural plasticity · 2014Review
- Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats.PloS one · 2014Article
- The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine.Translational psychiatry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neurogenesis in the dentate gyrus of the hippocampus of adult laboratory animals has been widely reported to be vulnerable to many psychological and physical stressors. However, we have found no effects of acute restraint stress, acute or subchronic tailshock stress, or acute, subchronic, or chronic resident-intruder stress on neural progenitor cell (NPC) proliferation, short or long term survival of newborn cells, or brain-derived neurotrophic factor (BDNF) mRNA expression in adult rats. In addition, we did not observe any effect of chronic resident-intruder stress on NPC proliferation in adolescent rats. A selectively bred stress-sensitive line was also found to exhibit no alterations in NPC proliferation following tailshock stress, although this line did exhibit a lower proliferation rate under baseline (unstressed) conditions when compared with non-selected rats. These results challenge the prevailing hypothesis that any stressor of sufficient intensity and duration has a marked negative impact upon the rate of hippocampal neurogenesis, and suggest that some yet unidentified factors related to stress and experimental conditions are crucial in the regulation of neurogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.