ArticleDevelopmental biology2011
Mesenchymal and mechanical mechanisms of secondary cartilage induction.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 81 citations in OpenAlex.
- Bibliometric analysis of enthesis research: a comprehensive review from 1999 to 2024.International orthopaedics · 2026Review
- Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease.Journal of anatomy · 2026Article
- Matrix components in the developing bones and cartilage of embryonic chick skulls: an in situ hybridization study.Anatomical science international · 2026Article
- Unbalanced occlusal loading elicited remodeling responses in growing rat temporomandibular joints and Notch1/Hes1 signaling pathway expression.BMC oral health · 2025Article
- Cellular, Molecular, and Genetic Mechanisms of Avian Beak Development and Evolution.Annual review of genetics · 2024Review
- The effects of dietary loading on the transdifferentiation of condylar chondrocytes.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2024Article
- Rapid specialization and stiffening of the primitive matrix in developing articular cartilage and meniscus.Acta biomaterialia · 2023Article
- Short-term effects of mechanical loading on the transdifferentiation of condylar chondrocytes.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2023Article
- Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions.Advances in anatomy, embryology, and cell biology · 2023Article
- Hot spots and frontiers in bone-tendon interface research: a bibliometric analysis and visualization from 2000 to 2023.Frontiers in surgery · 2023Review
- Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse.Journal of applied oral science : revista FOB · 2023Article
- Evolution and development of the mammalian jaw joint: Making a novel structure.Evolution & development · 2023Review
- The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Article
- Early shape divergence of developmental trajectories in the jaw of galeomorph sharks.Frontiers in zoology · 2022Article
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- Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Review
- Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Secondary cartilage occurs at articulations, sutures, and muscle attachments, and facilitates proper kinetic movement of the skeleton. Secondary cartilage requires mechanical stimulation for its induction and maintenance, and accordingly, its evolutionary presence or absence reflects species-specific variation in functional anatomy. Avians illustrate this point well. In conjunction with their distinct adult mode of feeding via levered straining, duck develop a pronounced secondary cartilage at the insertion (i.e., enthesis) of the mandibular adductor muscles on the lower jaw skeleton. An equivalent cartilage is absent in quail, which peck at their food. We hypothesized that species-specific pattern and a concomitant dissimilarity in the local mechanical environment promote secondary chondrogenesis in the mandibular adductor enthesis of duck versus quail. To test our hypothesis we employed two experimental approaches. First, we transplanted neural crest mesenchyme (NCM) from quail into duck, which produced chimeric "quck" with a jaw complex resembling that of quail, including an absence of enthesis secondary cartilage. Second, we modified the mechanical environment in embryonic duck by paralyzing skeletal muscles, and by blocking the ability of NCM to support mechanotransduction through stretch-activated ion channels. Paralysis inhibited secondary cartilage, as evidenced by changes in histology and expression of genes that affect chondrogenesis, including members of the FGF and BMP pathways. Ion channel inhibition did not alter enthesis secondary cartilage but caused bone to form in place of secondary cartilage at articulations. Thus, our study reveals that enthesis secondary cartilage forms through mechanisms that are distinct from those regulating other secondary cartilage. We conclude that by directing the musculoskeletal patterning and integration of the jaw complex, NCM modulates the mechanical forces and molecular signals necessary to control secondary cartilage formation during development and evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.