ArticleEnvironmental health : a global access science source2011
Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study.
Article in Environmental health : a global access science source, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments.Journal of the American Heart Association · 2013Trial
- Ambient temperature and biomarkers of heart failure: a repeated measures analysis.Environmental health perspectives · 2012Trial
- Article
- MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy.Frontiers in pharmacology · 2022Article
- Exposure to particulate matter: a brief review with a focus on cardiovascular effects, children, and research conducted in Turkey.Arhiv za higijenu rada i toksikologiju · 2021Review
- Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation.Environmental research · 2020Article
- A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers.Human genetics · 2019Review
- Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study.Environmental research · 2019Article
- Fine Particulate Matter Exposure and Cerebrospinal Fluid Markers of Vascular Injury.Journal of Alzheimer's disease : JAD · 2019Article
- The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress.Antioxidants & redox signaling · 2018Review
- Concentration-dependent effects of PMEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Occupational vehicle-related particulate exposure and inflammatory markers in trucking industry workers.Environmental research · 2016Article
- Air particulate matter and cardiovascular disease: the epidemiological, biomedical and clinical evidence.Journal of thoracic disease · 2016Review
- Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells.Oncotarget · 2015Article
- Repeated measures of inflammation, blood pressure, and heart rate variability associated with traffic exposures in healthy adults.Environmental health : a global access science source · 2015Article
- MicroRNA biogenesis and cellular proliferation.Translational research : the journal of laboratory and clinical medicine · 2015Article
- Ambient particulate air pollution and microRNAs in elderly men.Epidemiology (Cambridge, Mass.) · 2014Article
- Environmental exposures, epigenetics and cardiovascular disease.Current opinion in clinical nutrition and metabolic care · 2012Review
- Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort.Epidemiology (Cambridge, Mass.) · 2012Article
- Structural equation modeling of the inflammatory response to traffic air pollution.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundParticulate air pollution has been associated with cardiovascular morbidity and mortality, but it remains unclear which time windows and pollutant sources are most critical. MicroRNA (miRNA) is thought to be involved in cardiovascular regulation. However, little is known about whether polymorphisms in genes that process microRNAs influence response to pollutant exposure. We hypothesized that averaging times longer than routinely measured one or two day moving averages are associated with higher soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) levels, and that stationary and mobile sources contribute differently to these effects. We also investigated whether single nucleotide polymorphisms (SNPs) in miRNA-processing genes modify these associations.
methodssICAM-1 and sVCAM-1 were measured from 1999-2008 and matched to air pollution monitoring for fine particulate matter (PM2.5) black carbon, and sulfates (SO42-). We selected 17 SNPs in five miRNA-processing genes. Mixed-effects models were used to assess effects of pollutants, SNPs, and interactions under recessive inheritance models using repeated measures.
results723 participants with 1652 observations and 1-5 visits were included in our analyses for black carbon and PM2.5. Sulfate data was available for 672 participants with 1390 observations. An interquartile range change in seven day moving average of PM2.5 (4.27 μg/m3) was associated with 3.1% (95%CI: 1.6, 4.6) and 2.5% (95%CI: 0.6, 4.5) higher sICAM-1 and sVCAM-1. Interquartile range changes in sulfates (1.39 μg/m3) were associated with 1.4% higher (95%CI: 0.04, 2.7) and 1.6% (95%CI: -0.4, 3.7) higher sICAM-1 and sVCAM-1 respectively. No significant associations were observed for black carbon. In interaction models with PM2.5, both sICAM-1 and sVCAM-1 levels were lower in rs1062923 homozygous carriers. These interactions remained significant after multiple comparisons adjustment.
conclusionsPM2.5 seven day moving averages are associated with higher sICAM-1 and sVCAM-1 levels. SO4-2 seven day moving averages are associated with higher sICAM-1 and a suggestive association was observed with sVCAM-1 in aging men. SNPs in miRNA-processing genes may modify associations between ambient pollution and sICAM-1 and sVCAM-1, which are correlates of atherosclerosis and cardiovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.