ArticleBMC plant biology2011
Apple skin patterning is associated with differential expression of MYB10.
Article in BMC plant biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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Who cites it
129 citing papers in PubMed, 296 citations in OpenAlex.
- Multifaceted mechanisms underlying species- and cultivar-associated differential anthocyanin accumulation in fruits.Horticulture research · 2026Article
- Molecular Mechanisms and Regulation of Anthocyanin Biosynthesis in Rosaceae Fruits: A Review.Food science & nutrition · 2026Review
- ReducedPlants (Basel, Switzerland) · 2026Article
- Molecular insights into the regulation of flavonoid biosynthesis in fruits.Horticulture research · 2026Article
- Environmental control of anthraquinone-flavonoid accumulation in wild plant species: biosynthetic pathways, ecological drivers, and adaptive significance.Frontiers in plant science · 2026Review
- Natural variations in MdBPM2/MdRGLG3-MdNAC83 network controlling the quantitative segregation of apple fruit storability.Journal of integrative plant biology · 2026Article
- Transcriptomic and Metabolic Profiles of Apple Peels of Different Colors.Plants (Basel, Switzerland) · 2025Article
- The KNOX transcription factor ClSP activates ClAPRR2 to regulate dark green stripe formation in watermelon.Plant biotechnology journal · 2025Article
- DNA Methylation Profile Changes in CpG Islands of Ethylene-Signaling Genes Regulated by Melatonin Were Involved in Alleviating Chilling Injury of Postharvest Tomato Fruit.International journal of molecular sciences · 2025Article
- Molecular Mimicry of Transposable Elements in Plants.Plant & cell physiology · 2025Review
- Identification of key genes controlling anthocyanin biosynthesis in the fruits of a bud variety of Tarocco blood-orange.BMC plant biology · 2025Article
- Review
- DNA Methylation Is Crucial for 1-Methylcyclopropene Delaying Postharvest Ripening and Senescence of Tomato Fruit.International journal of molecular sciences · 2024Article
- Single-Base Methylome Analysis of Sweet Cherry (International journal of molecular sciences · 2024Article
- Identifying potential anthocyanin biosynthesis regulator in Chinese cherry by comprehensive genome-wide characterization of the R2R3-MYB transcription factor gene family.BMC genomics · 2024Article
- Preventing too much of a good thing: epigenetic regulation limits sucrose-induced anthocyanin production in Arabidopsis.The New phytologist · 2024Article
- The Expression of Key Ethylene and Anthocyanin Biosynthetic Genes of 'Honeycrisp' Apples Subjected to the Combined Use of Reflective Groundcovers and Aminoethoxyvinylglycine in the Mid-Atlantic US.Plants (Basel, Switzerland) · 2024Article
- Hypermethylation in the promoter regions of flavonoid pathway genes is associated with skin color fading during 'Daihong' apple fruit development.Horticulture research · 2024Article
- Article
- Fade into you: genetic control of pigmentation patterns in red-flesh apple (Frontiers in plant science · 2024Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome apple (Malus × domestica Borkh.) varieties have attractive striping patterns, a quality attribute that is important for determining apple fruit market acceptance. Most apple cultivars (e.g. 'Royal Gala') produce fruit with a defined fruit pigment pattern, but in the case of 'Honeycrisp' apple, trees can produce fruits of two different kinds: striped and blushed. The causes of this phenomenon are unknown.
resultsHere we show that striped areas of 'Honeycrisp' and 'Royal Gala' are due to sectorial increases in anthocyanin concentration. Transcript levels of the major biosynthetic genes and MYB10, a transcription factor that upregulates apple anthocyanin production, correlated with increased anthocyanin concentration in stripes. However, nucleotide changes in the promoter and coding sequence of MYB10 do not correlate with skin pattern in 'Honeycrisp' and other cultivars differing in peel pigmentation patterns. A survey of methylation levels throughout the coding region of MYB10 and a 2.5 Kb region 5' of the ATG translation start site indicated that an area 900 bp long, starting 1400 bp upstream of the translation start site, is highly methylated. Cytosine methylation was present in all three contexts, with higher methylation levels observed for CHH and CHG (where H is A, C or T) than for CG. Comparisons of methylation levels of the MYB10 promoter in 'Honeycrisp' red and green stripes indicated that they correlate with peel phenotypes, with an enrichment of methylation observed in green stripes.
conclusionsDifferences in anthocyanin levels between red and green stripes can be explained by differential transcript accumulation of MYB10. Different levels of MYB10 transcript in red versus green stripes are inversely associated with methylation levels in the promoter region. Although observed methylation differences are modest, trends are consistent across years and differences are statistically significant. Methylation may be associated with the presence of a TRIM retrotransposon within the promoter region, but the presence of the TRIM element alone cannot explain the phenotypic variability observed in 'Honeycrisp'. We suggest that methylation in the MYB10 promoter is more variable in 'Honeycrisp' than in 'Royal Gala', leading to more variable color patterns in the peel of this cultivar.
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