ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2011
Mechanics of membrane bulging during cell-wall disruption in gram-negative bacteria.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
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- Mapping single-cell responses to population-level dynamics during antibiotic treatment.Molecular systems biology · 2023Article
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- Understanding Beta-Lactam-Induced Lysis at the Single-Cell Level.Frontiers in microbiology · 2021Article
- Aberrant Membrane Structures in HypervesiculatingFrontiers in microbiology · 2021Article
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- Mechanics and Dynamics of Bacterial Cell Lysis.Biophysical journal · 2019Article
- Electropermeabilization of nematode eggs for parasite deactivation.Journal of water, sanitation, and hygiene for development : a journal of the International Water Association · 2019Article
- Distribution of mechanical stress in the Escherichia coli cell envelope.Biochimica et biophysica acta. Biomembranes · 2018Article
- Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action.Cellular and molecular life sciences : CMLS · 2016Review
- Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2014Article
- Critical cell wall hole size for lysis in Gram-positive bacteria.Journal of the Royal Society, Interface · 2013Article
- Distinct single-cell morphological dynamics under beta-lactam antibiotics.Molecular cell · 2012Article
- The molecular origins of chiral growth in walled cells.Current opinion in microbiology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The bacterial cell wall is a network of sugar strands crosslinked by peptides that serve as the primary structure for bearing osmotic stress. Despite its importance in cellular survival, the robustness of the cell wall to network defects has been relatively unexplored. Treatment of the gram-negative bacterium Escherichia coli with the antibiotic vancomycin, which disrupts the crosslinking of new material during growth, leads to the development of pronounced bulges and eventually of cell lysis. Here, we model the mechanics of the bulging of the cytoplasmic membrane through pores in the cell wall. We find that the membrane undergoes a transition between a nearly flat state and a spherical bulge at a critical pore radius of ~20 nm. This critical pore size is large compared to the typical distance between neighboring peptides and glycan strands, and hence pore size acts as a constraint on network integrity. We also discuss the general implications of our model to membrane deformations in eukaryotic blebbing and vesiculation in red blood cells.
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