ArticleOrganic letters2011
Multicomponent assembly and diversification of novel heterocyclic scaffolds derived from 2-arylpiperidines.
Article in Organic letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Design, Synthesis, and Evaluation of Novel Anti-Trypanosomal Compounds.Tetrahedron · 2020Article
- Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins.Beilstein journal of organic chemistry · 2018Article
- Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands.ChemMedChem · 2016Article
- A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.Organic & biomolecular chemistry · 2016Article
- Applications of Ring Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine.Tetrahedron · 2015Article
- Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification.Organic & biomolecular chemistry · 2014Review
- Multicomponent, Mannich-type assembly process for generating novel, biologically-active 2-arylpiperidines and derivatives.Tetrahedron · 2014Article
- Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions.Angewandte Chemie (International ed. in English) · 2012Article
- Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.ACS combinatorial science · 2012Article
- Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids.Tetrahedron letters · 2012Article
- Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.ACS combinatorial science · 2012Article
- APPLICATIONS OF MULTICOMPONENT ASSEMBLY PROCESSES TO THE FACILE SYNTHESES OF DIVERSELY FUNCTIONALIZED NITROGEN HETEROCYCLES.Heterocycles · 2012Article
- Facile Syntheses of Substituted, Conformationally-Constrained Benzoxazocines and Benzazocines via Sequential Multicomponent Assembly and Cyclization.Tetrahedron letters · 2011Article
- Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.Organic letters · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A collection of structurally diverse, polyheterocyclic scaffolds comprising a 2-arylpiperidine subunit were synthesized using a Mannich-type multicomponent assembly process, followed by appropriately sequenced ring-forming reactions. An improved procedure for removal of N-4-pentenoyl groups was developed; one-pot sequences for tandem urea/thiourea formation and cyclization and tandem enolate arylation/alkylation were discovered. A novel entry to bridged tetrahydroquinoline scaffolds exploiting A(1,3) strain was also invented. Derivatization of several scaffolds was achieved by cross-coupling and N-functionalization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.