ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2012
Peripheral T regulatory cells and cytokines in hepatitis E infection.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Pathogenesis and clinical features of severe hepatitis E virus infection.World journal of virology · 2024Review
- Hepatitis E infection: A review.World journal of virology · 2023Review
- Author's reply.CEN case reports · 2023Article
- Hepatitis E virus infection-induced complete remission of primary membranous nephropathy through its higher propensity for inducing regulatory T cells.CEN case reports · 2023Article
- Complete remission of primary membranous nephropathy following hepatitis E infection.CEN case reports · 2023Article
- The Role of Cluster of Differentiation 39 (CD39) and Purinergic Signaling Pathway in Viral Infections.Pathogens (Basel, Switzerland) · 2023Review
- Article
- Regulatory Role of B Cells and Its Subsets in Hepatitis E Virus Infection.BioMed research international · 2022Article
- Review
- Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors.International journal of molecular sciences · 2021Review
- Current Paradigm of Hepatitis E Virus Among Pediatric and Adult Patients.Frontiers in pediatrics · 2021Review
- Immunological Manifestations of Hepatitis E-Associated Acute and Chronic Liver Failure and Its Regulatory Mechanisms.Frontiers in medicine · 2021Review
- Clinical features and determinants of chronicity in hepatitis E virus infection.Journal of viral hepatitis · 2019Review
- Acute-on-chronic liver failure: recent update.Journal of biomedical research · 2017Article
- Hepatitis E Pathogenesis.Viruses · 2016Review
- Acute-on-chronic liver failure: terminology, mechanisms and management.Nature reviews. Gastroenterology & hepatology · 2016Review
- Altered profile of regulatory T cells and associated cytokines in mild and moderate dengue.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Hepatitis E virus infection: Epidemiology and treatment implications.World journal of virology · 2015Review
- Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study addresses the involvement of regulatory T cells in hepatitis E (HE) infection. The study population comprised 77 acute viral HE patients, 52 recovered individuals (overall, 129 individuals with HE) and 53 healthy controls. Peripheral CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(-)Foxp3(+) frequencies by flow cytometry and HE-specific cytokines/chemokines quantitation were carried out. The median percentage of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(-)Foxp3(+) T cells in acute patients were significantly higher compared to controls and recovered individuals. Both of the T regulatory (Treg) subset populations in overall HE were significantly elevated compared to controls. Comparisons of cytokines/chemokines revealed that the levels of IL-10 were elevated in: (a) acute viral hepatitis E (AVH-E) versus recovered individuals and controls, and (b) HE versus controls. Overall, the elevation of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(-)Foxp3(+) frequencies and the rise in IL-10 suggest that Treg cells might be playing a pivotal role in hepatitis E virus (HEV) infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.