SynthesisEuropean radiology2011
Influence of coronary artery disease prevalence on predictive values of coronary CT angiography: a meta-regression analysis.
Synthesis in European radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data.BMJ (Clinical research ed.) · 2019Pooled it
- The diagnostic performance of coronary artery angiography with 64-MSCT and post 64-MSCT: systematic review and meta-analysis.PloS one · 2014Pooled it
- Use of 3x2 tables with an intention to diagnose approach to assess clinical performance of diagnostic tests: meta-analytical evaluation of coronary CT angiography studies.BMJ (Clinical research ed.) · 2012Pooled it
- Trial
- Computed tomography versus invasive coronary angiography: design and methods of the pragmatic randomised multicentre DISCHARGE trial.European radiology · 2017Trial
- Evaluation of computed tomography in patients with atypical angina or chest pain clinically referred for invasive coronary angiography: randomised controlled trial.BMJ (Clinical research ed.) · 2016Trial
- Utility of Coronary Computed Tomography Angiography in Patients Undergoing Transcatheter Aortic Valve Implantation: A Meta-Analysis and Meta-Regression Based on Published Data from 7458 Patients.Journal of clinical medicine · 2024Article
- Incremental role of CT coronary angiography in the assessment of left ventricular diastolic function.Open heart · 2021Article
- Effects of epicardial adipose tissue volume and density on cardiac structure and function in patients free of coronary artery disease.Japanese journal of radiology · 2020Article
- Extracardiac findings on coronary computed tomography angiography in patients without significant coronary artery disease.European radiology · 2019Article
- Applicability and accuracy of pretest probability calculations implemented in the NICE clinical guideline for decision making about imaging in patients with chest pain of recent onset.European radiology · 2018Article
- Association between red cell distribution width and the risk of heart events in patients with coronary artery disease.Experimental and therapeutic medicine · 2015Article
- Article
- Noninvasive physiologic assessment of coronary stenoses using cardiac CT.BioMed research international · 2015Review
- Article
- Beyond Trisomy 21: Additional Chromosomal Anomalies Detected through Routine Aneuploidy Screening.Journal of clinical medicine · 2014Review
- Postmortem imaging of sudden cardiac death.International journal of legal medicine · 2014Review
- Article
- Fully automated derivation of coronary artery calcium scores and cardiovascular risk assessment from contrast medium-enhanced coronary CT angiography studies.European radiology · 2013Article
- Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT).Systematic reviews · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the impact of coronary artery disease (CAD) prevalence on the predictive values of coronary CT angiography.
methodsWe performed a meta-regression based on a generalised linear mixed model using the binomial distribution and a logit link to analyse the influence of the prevalence of CAD in published studies on the per-patient negative and positive predictive values of CT in comparison to conventional coronary angiography as the reference standard. A prevalence range in which the negative predictive value was higher than 90%, while at the same time the positive predictive value was higher than 70% was considered appropriate.
resultsThe summary negative and positive predictive values of coronary CT angiography were 93.7% (95% confidence interval [CI] 92.8-94.5%) and 87.5% (95% CI, 86.5-88.5%), respectively. With 95% confidence, negative and positive predictive values higher than 90% and 70% were available with CT for a CAD prevalence of 18-63%. CT systems with >16 detector rows met these requirements for the positive (P < 0.01) and negative (P < 0.05) predictive values in a significantly broader range than systems with ≤16 detector rows.
conclusionIt is reasonable to perform coronary CT angiography as a rule-out test in patients with a low-to-intermediate likelihood of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.