ArticleInternational journal of legal medicine2011
Sensitivity and specificity of NT-proBNP to detect heart failure at post mortem examination.
Article in International journal of legal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Current Trends in Biohumoral Screening for the Risk of Sudden Cardiac Death: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Cost-effectiveness of B-type natriuretic peptide-guided care in patients with heart failure: a systematic review.Heart failure reviews · 2018Pooled it
- Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology.Virchows Archiv : an international journal of pathology · 2017Guideline
- 8-OHdG and NT-proBNP as complementary biomarkers in the postmortem diagnosis of acute ischemic heart disease.Scientific reports · 2026Article
- Assessment of cardiac biomarker "point-of-care" testing as postmortem diagnostic tool.International journal of legal medicine · 2025Article
- Lowering B-type natriuretic peptide levels and increasing cardiac function: the role of levosimendan in the treatment of heart failure.The Journal of international medical research · 2025Article
- Combined determination of B-type natriuretic peptide and high-sensitivity troponin I in the postmortem diagnosis of cardiac disease.Forensic science, medicine, and pathology · 2019Article
- BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine.International journal of molecular sciences · 2019Review
- Differential expression of B-type natriuretic peptide between left and right ventricles, with particular regard to sudden cardiac death.Molecular medicine reports · 2017Article
- Highly sensitive detection of NT-proBNP by molecular motor.Genes & diseases · 2017Article
- Elevation of NT-proBNP and cardiac troponins in sepsis-related deaths: a forensic perspective.International journal of legal medicine · 2016Article
- Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis.International journal of legal medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NT-proBNP, a marker of cardiac failure, has been shown to be stable in post mortem samples. The aim of this study was to assess the accuracy of NT-proBNP to detect heart failure in the forensic setting. One hundred sixty-eight consecutive autopsies were included in the study. NT-proBNP blood concentrations were measured using a chemiluminescent immunoassay kit. Cardiac failure was assessed by three independent forensic experts using macro- and microscopic findings complemented by information about the circumstances of body discovery and the known medical story. Area under the receiving operator curve was of 65.4% (CI 95%, from 57.1 to 73.7). Using a standard cut-off value of >220 pg/mL for NT-proBNP blood concentration, heart failure was detected with a sensitivity of 50.7% and a specificity of 72.6%. NT-proBNP vitreous humor values were well correlated to the ones measured in blood (r (2) = 0.658). Our results showed that NT-proBNP can corroborate the pathological findings in cases of natural death related to heart failure, thus, keeping its diagnostic properties passing from the ante mortem to the post mortem setting. Therefore, biologically inactive polypeptides like NT-proBNP seem to be stable enough to be used in forensic medicine as markers of cardiac failure, taking into account the sensitivity and specificity of the test.
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