ArticleCells, tissues, organs2011
Abnormalities in the enamel in bmp2-deficient mice.
Article in Cells, tissues, organs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration.International journal of oral science · 2026Article
- Article
- Suffruticosol A elevates osteoblast differentiation targeting BMP2-Smad/1/5/8-RUNX2 in pre-osteoblasts.BioFactors (Oxford, England) · 2023Article
- CTR9 drives osteochondral lineage differentiation of human mesenchymal stem cells via epigenetic regulation of BMP-2 signaling.Science advances · 2022Article
- Review
- Crucial Roles of microRNA-16-5p and microRNA-27b-3p in Ameloblast Differentiation Through Regulation of Genes Associated With Amelogenesis Imperfecta.Frontiers in genetics · 2022Article
- Article
- BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation.Cell death & disease · 2021Article
- Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases.Frontiers in physiology · 2021Review
- Developmental Roles of FUSE Binding Protein 1 (International journal of molecular sciences · 2020Article
- Noggin inhibition of mouse dentinogenesis.Journal of oral biosciences · 2020Article
- Identification of dentinogenic cell-specific surface antigens in odontoblast-like cells derived from adult dental pulp.Stem cell research & therapy · 2019Article
- Regulatory mechanisms of jaw bone and tooth development.Current topics in developmental biology · 2019Review
- The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development.The Journal of biological chemistry · 2018Article
- The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis.Archives of oral biology · 2018Article
- BMP signalling in skeletal development, disease and repair.Nature reviews. Endocrinology · 2016Review
- Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes.Cell and tissue research · 2016Article
- Establishment of Immortalized Mouse Bmp2 Knock-Out Dental Papilla Mesenchymal Cells Necessary for Study of Odontoblastic Differentiation and Odontogenesis.Journal of cellular physiology · 2015Article
- Bmp2 deletion causes an amelogenesis imperfecta phenotype via regulating enamel gene expression.Journal of cellular physiology · 2015Article
- Long bone structure and strength depend on BMP2 from osteoblasts and osteocytes, but not vascular endothelial cells.PloS one · 2014Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation. However, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in the regulation of postnatal enamel formation was investigated via the conditional ablation of Bmp2 in enamel using the (Osx-Cre) mouse. Bmp2 gene ablation was confirmed by PCR analysis in Osx-Cre, Bmp2(flox/flox) mice. Bmp2-null mice displayed a severe and profound tooth phenotype with asymmetric and open forked incisors. Microradiographs revealed broken incisor tips and dental pulp chamber exposure. The enamel layer of incisors and molars was thin with hypomineralization. Scanning electron microscopy analysis showed that the enamel surface was rough with chipping and the enamel lacked a typical prismatic architecture. These results demonstrate that Bmp2 is essential for enamel formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.