ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2011
B-vitamin deficiency is protective against DSS-induced colitis in mice.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study.BMC medicine · 2023Pooled it
- Correlations of MTHFR 677C>T polymorphism with cardiovascular disease in patients with end-stage renal disease: a meta-analysis.PloS one · 2014Pooled it
- The Association of Nutrient Patterns and Risk of Ulcerative Colitis: A Case-Control Study.Crohn's & colitis 360 · 2025Article
- S1P Lyase Inhibition Increased Intestinal S1P, Disrupted the Intestinal Barrier and Aggravated DSS-Induced Colitis.Inflammatory bowel diseases · 2025Article
- Article
- Vitamin B12 ameliorates gut epithelial injury via modulating the HIF-1 pathway and gut microbiota.Cellular and molecular life sciences : CMLS · 2024Article
- Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats.International journal of preventive medicine · 2024Article
- Vitamin BNature metabolism · 2023Article
- Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome.mSystems · 2023Article
- Genetically predicted levels of folate, vitamin BFrontiers in immunology · 2023Article
- Vitamin B12 coordinates ileal epithelial cell and microbiota functions to resist Salmonella infection in mice.The Journal of experimental medicine · 2022Article
- B Vitamins and Their Roles in Gut Health.Microorganisms · 2022Review
- Pyridoxal 5'-Phosphate-Dependent Enzymes at the Crossroads of Host-Microbe Tryptophan Metabolism.International journal of molecular sciences · 2020Review
- Vitamin B12 Deficiency Alters the Gut Microbiota in a Murine Model of Colitis.Frontiers in nutrition · 2020Article
- B-Vitamin Sharing Promotes Stability of Gut Microbial Communities.Frontiers in microbiology · 2019Article
- Oral vitamin BGut microbes · 2019Article
- Vitamins and Minerals in Inflammatory Bowel Disease.Gastroenterology clinics of North America · 2017Review
- Ginseng Berry Extract Attenuates Dextran Sodium Sulfate-Induced Acute and Chronic Colitis.Nutrients · 2016Article
- Cystathionine β-synthase-deficient mice thrive on a low-methionine diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease.The Journal of nutritional biochemistry · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Vitamin deficiencies are common in patients with inflammatory bowel disease (IBD). Homocysteine (Hcys) is a thrombogenic amino acid produced from methionine (Met), and its increase in patients with IBD indicates a disruption of Met metabolism; however, the role of Hcys and Met metabolism in IBD is not well understood. We hypothesized that disrupted Met metabolism from a B-vitamin-deficient diet would exacerbate experimental colitis. Mice were fed a B(6)-B(12)-deficient or control diet for 2 wk and then treated with dextran sodium sulfate (DSS) to induce colitis. We monitored disease activity during DSS treatment and collected plasma and tissue for analysis of inflammatory tissue injury and Met metabolites. We also quantified Met cycle activity by measurements of in vivo Met kinetics using [1-(13)C-methyl-(2)H(3)]methionine infusion in similarly treated mice. Unexpectedly, we found that mice given the B-vitamin-deficient diet had improved clinical outcomes, including increased survival, weight maintenance, and reduced disease scores. We also found lower histological disease activity and proinflammatory gene expression (TNF-α and inducible nitric oxide synthase) in the colon in deficient-diet mice. Metabolomic analysis showed evidence that these effects were associated with deficient B(6), as markers of B(12) function were only mildly altered. In vivo methionine kinetics corroborated these results, showing that the deficient diet suppressed transsulfuration but increased remethylation. Our findings suggest that disrupted Met metabolism attributable to B(6) deficiency reduces the inflammatory response and disease activity in DSS-challenged mice. These results warrant further human clinical studies to determine whether B(6) deficiency and elevated Hcys in patients with IBD contribute to disease pathobiology.
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Registered trials
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