Evidence map›Paper›PMID 21596926›Full record

ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011

Thrombosis, physical activity, and acute coronary syndromes.

Arun Kumar, Subrata Kar, William P Fay

Open access · greenAbstract readReview
In one paragraph

Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arun KumarDepartment of Internal Medicine, University of Missouri-Columbia School of Medicine, 5 Hospital Dr., Columbia, MO 65212, USA. kumararun@health.missouri.edu
Subrata Kar
William P Fay
Harry S. Truman Memorial Veterans' Hospital · US

Funding

TRANSGENIC MODELS FOR THE STUDY OF FACTOR V FUNCTIONP01HL057346 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAUFMAN, RANDAL J. · 1997 to 2013
$19.9M
Roles of Plasminogen Activator Inhibitor-1 and Vitronectin in Failure of CoronaryR01HL095951 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI FAY, WILLIAM P · 2010 to 2013
$1.5M
NHLBI NIH HHS HL-095951NHLBI NIH HHS HL-57346
6 · The paper itself

Abstract

Acute coronary syndromes (ACS) are common, life-threatening cardiac disorders that typically are triggered by rupture or erosion of an atherosclerotic plaque. Platelet deposition and activation of the blood coagulation cascade in response to plaque disruption lead to the formation of a platelet-fibrin thrombus, which can grow rapidly, obstruct coronary blood flow, and cause myocardial ischemia and/or infarction. Several clinical studies have examined the relationship between physical activity and ACS, and numerous preclinical and clinical studies have examined specific effects of sustained physical training and acute physical activity on atherosclerotic plaque rupture, platelet function, and formation and clearance of intravascular fibrin. This article reviews the available literature regarding the role of physical activity in determining the incidence of atherosclerotic plaque rupture and the pace and extent of thrombus formation after plaque rupture.

Indexed as

Acute Coronary SyndromeAtherosclerosisBlood CoagulationCoronary DiseaseCoronary ThrombosisFibrinolysisHumansMotor ActivityPlaque, AtheroscleroticPlatelet Aggregation

Identifiers

PMID21596926
PMCPMC3154689
OpenAlexW2083915112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.