ArticleJournal of medical microbiology2011
Genotyping of Mycobacterium leprae from Brazilian leprosy patients suggests the occurrence of reinfection or of bacterial population shift during disease relapse.
Article in Journal of medical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Genotypic investigation of Mycobacterium leprae in patients with relapsing leprosy in Mato Grosso, Brazil.Medical microbiology and immunology · 2025Article
- Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.Antimicrobial agents and chemotherapy · 2025Article
- Genomic and Phenotypic Variations Among Thai-53 andPathogens (Basel, Switzerland) · 2024Article
- Heterogeneous persistence of Mycobacterium leprae in oral and nasal mucosa of multibacillary patients during multidrug therapy.Memorias do Instituto Oswaldo Cruz · 2022Article
- Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: A 20-year cohort study in a brazilian reference center.PLoS neglected tropical diseases · 2021Observational
- Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment.Antimicrobial agents and chemotherapy · 2020Article
- Underlying mechanisms of leprosy recurrence in the Western Amazon: a retrospective cohort study.BMC infectious diseases · 2019Article
- Genotyping comparison of Mycobacterium leprae isolates by VNTR analysis from nasal samples in a Brazilian endemic region.Pathogens and global health · 2018Article
- Genotyping of Mycobacterium leprae for better understanding of leprosy transmission in Fortaleza, Northeastern Brazil.PLoS neglected tropical diseases · 2017Article
- Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases.PLoS neglected tropical diseases · 2017Article
- Uniform multidrug therapy for leprosy - time for a rethink?The Indian journal of medical research · 2016Article
- Human Genetic Ancestral Composition Correlates with the Origin of Mycobacterium leprae Strains in a Leprosy Endemic Population.PLoS neglected tropical diseases · 2015Article
- PCR-based techniques for leprosy diagnosis: from the laboratory to the clinic.PLoS neglected tropical diseases · 2014Review
- Mycobacterium leprae in Colombia described by SNP7614 in gyrA, two minisatellites and geography.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Drug and multidrug resistance among Mycobacterium leprae isolates from Brazilian relapsed leprosy patients.Journal of clinical microbiology · 2012Article
- Clinical-epidemiological profile of leprosy patients undergoing retreatment at a reference center in southeastern Brazil.Anais brasileiros de dermatologiaArticle
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
We performed genotyping of Mycobacterium leprae present in skin biopsy samples that were collected during the first and the second disease occurrences from eight leprosy patients, seven of whom were diagnosed as suffering from disease relapse. Sequence analysis of part of the M. leprae rpoB, folP1, gyrB and gyrA genes did not show genetic change that supported the presence of drug-resistant bacilli. However, we observed a synonymous nucleotide change at position 297 of gyrA among five of these patients, one presenting C to T (CgyrAT) and four presenting T to C (TgyrAC) at this position. Additional genotyping by analysis of the four short tandem repeats GAA, GTA9, AT17 and TA18 showed that the gyrA single nucleotide polymorphism change was accompanied by a change in short tandem repeat genotype. Our data suggest that leprosy relapse in these patients, living in an area endemic for leprosy, could be caused by M. leprae with a genotype different from the one that caused initial disease.
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