ArticleBlood2011
Two antioxidants are better than one.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Vitamin C supplementation does not improve hypoxia-induced erythropoiesis.High altitude medicine & biology · 2012Article
- Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New evidence suggests that the cellular oxygen-sensing hypoxia-inducible factor(HIF) pathway may be protected by a double buffer of cellular antioxidant defense. Key players in the oxygen-dependent regulation of this pathway are the prolyl hydroxylase domain-containing enzymes (PHDs) that catalyze the prolyl-4-hydroxylation of HIFα, dependent on the presence of oxygen, 2-oxoglutarate, and iron in the ferrous (Fe(2+)) form. Vitamin C is also required as a cofactor, possibly to maintain the catalytic iron center in its functional Fe(2+)) state, although both the mechanism and the in vivo requirement are not absolutely clear.
Identifiers
21596862What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.