ArticleAJNR. American journal of neuroradiology2011
Mechanical characterization of thromboemboli in acute ischemic stroke and laboratory embolus analogs.
Article in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.
- Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.Journal of neurointerventional surgery · 2017Pooled it
- Partial (SAVE) versus Complete (Solumbra) Stent Retriever Retraction Technique for Mechanical Thrombectomy: A Randomized In Vitro Study.AJNR. American journal of neuroradiology · 2023Trial
- Eccentric rheometry for viscoelastic characterization of small, soft, anisotropic, and irregularly shaped biopolymer gels and tissue biopsies.Annals of biomedical engineering · 2012Trial
- Mechanical Characterization of Fibrin-Based Blood Clot Analogues for Modeling Intracerebral Hemorrhage.Annals of biomedical engineering · 2026Article
- Beyond the Catheter: Contemporary Aspiration Pump Systems in Neurointerventional Stroke Therapy.Stroke (Hoboken, N.J.) · 2026Review
- Clinical image analysis to build patient-specific models of acute ischemic stroke patients.Physical and engineering sciences in medicine · 2026Article
- A novel method for preparing clot analogs under dynamic vortical flow for testing mechanical thrombectomy devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Development of physiologically relevant synthetic thrombus for use in visual analysis of in vitro mechanical thrombectomy device testing.Journal of neurointerventional surgery · 2025Article
- Milli-spinner thrombectomy.Nature · 2025Article
- Understanding embolus transport and source to destination mapping of thromboemboli in hemodynamics driven by left ventricular assist device.Scientific reports · 2025Article
- Histopathological composition of thrombus material in a large cohort of patients with acute ischemic stroke: a study of atypical clots.Frontiers in neurology · 2025Article
- Unraveling the Enigma: Correlating Thrombus Histopathology With the Number of Passes in Mechanical Thrombectomy.Cureus · 2025Article
- Preventing Embolization to a New Vascular Territory: An in Vitro Study Exploring Alternative Techniques for Dual-Stent-Retriever Cerebral Thrombectomy.Journal of neuroendovascular therapy · 2025Article
- Impact of Target Artery Size on the Performance of Aspiration Thrombectomy: Insights from a Swine Model with Real-Time Visualization.AJNR. American journal of neuroradiology · 2024Article
- Dynamic Perviousness: A Novel Imaging Marker for Predicting Mechanical Thrombectomy Outcomes in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Material strengths of shear-induced platelet aggregation clots and coagulation clots.Scientific reports · 2024Article
- In silico analysis of embolism in cerebral arteries using fluid-structure interaction method.Heliyon · 2024Article
- Clot-based time attenuation curve as a novel imaging predictor of mechanical thrombectomy functional outcome in acute ischemia stroke.European radiology · 2024Article
- Aortogenic calcified cerebral embolism diagnosed with an embolus retrieved by thrombectomy: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Microfabricated Nitinol Stent Retrievers with a Micro-Patterned Surface.Micromachines · 2024Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeMechanical behavior of the thromboembolus is one of the key factors that determine the efficacy of thrombectomy devices for revascularization in AIS. We characterized the mechanical properties and composition of thromboemboli from clinical cases and compared them with commonly used EAs. MATERIALS AND
methodsThromboemboli were obtained from patients with AIS by using aspiration devices and from carotid atherosclerotic plaques harvested during endarterectomy. In the laboratory, common EAs were created by varying blood donor species (human, porcine, and bovine), thrombin concentration, and presence of barium sulfate. Stiffness and elasticity of the specimens were measured with DMA. Scanning electron microscopy and histology were used to investigate the ultrastructure and composition of all specimens.
resultsRed thromboemboli from patients composed mainly of fibrin and erythrocytes were much softer than the calcified and cholesterol-rich material. Of the EAs created in the laboratory, those made from bovine blood presented the highest stiffness that was independent of thrombin concentration. Addition of thrombin increased the stiffness and elasticity of human and porcine EAs (P < .05). The presence of barium sulfate significantly reduced the elasticity of all EAs (P < .05).
conclusionsEndovascular device testing and development requires realistic EAs. The stiffness and elasticity of the cerebral thromboemboli analyzed in this study were closely matched by recalcified porcine EAs and thrombin-induced human EAs. Stiffness of the thrombus extracted from carotid endarterectomy specimens was similar with that of the thrombin-induced bovine and porcine EAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.