ArticleBioinformatics (Oxford, England)2011
Bioinformatics challenges for personalized medicine.
Article in Bioinformatics (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical decision support for genetically guided personalized medicine: a systematic review.Journal of the American Medical Informatics Association : JAMIAPooled it
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- Assessment of Diagnosis, Prognosis and Immune Infiltration Response to the Expression of the Ferroptosis-Related Molecule HAMP in Clear Cell Renal Cell Carcinoma.International journal of environmental research and public health · 2023Article
- Evaluating the relevance of sequence conservation in the prediction of pathogenic missense variants.Human genetics · 2022Article
- ELIMINATOR: essentiality analysis using multisystem networks and integer programming.BMC bioinformatics · 2022Article
- Assessment of deep learning and transfer learning for cancer prediction based on gene expression data.BMC bioinformatics · 2022Article
- Predicting functional consequences of mutations using molecular interaction network features.Human genetics · 2022Article
- Bioinformatic Challenges Detecting Genetic Variation in Precision Medicine Programs.Frontiers in medicine · 2022Review
- Analysis and Interpretation of the Impact of Missense Variants in Cancer.International journal of molecular sciences · 2021Review
- A spatial neighborhood methodology for computing and analyzing lymph node carcinoma similarity in precision medicine.Journal of biomedical informatics · 2020Article
- Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants.Human mutation · 2019Article
- Fido-SNP: the first webserver for scoring the impact of single nucleotide variants in the dog genome.Nucleic acids research · 2019Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
motivationWidespread availability of low-cost, full genome sequencing will introduce new challenges for bioinformatics.
resultsThis review outlines recent developments in sequencing technologies and genome analysis methods for application in personalized medicine. New methods are needed in four areas to realize the potential of personalized medicine: (i) processing large-scale robust genomic data; (ii) interpreting the functional effect and the impact of genomic variation; (iii) integrating systems data to relate complex genetic interactions with phenotypes; and (iv) translating these discoveries into medical practice. CONTACT: russ.altman@stanford.edu
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.