ArticleThe Journal of biological chemistry2011
Characterization of a dipartite iron uptake system from uropathogenic Escherichia coli strain F11.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance.Archives of microbiology · 2025Review
- Dissecting components of theMicrobiology spectrum · 2024Article
- Emerging Non-Antibiotic Options Targeting Uropathogenic Mechanisms for Recurrent Uncomplicated Urinary Tract Infection.International journal of molecular sciences · 2023Review
- Characterization of siderophores from Escherichia coli strains through genome mining tools: an antiSMASH study.AMB Express · 2022Article
- Crystal structure and metal binding properties of the periplasmic iron component EfeM from Pseudomonas syringae EfeUOB/M iron-transport system.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- The fciTABC and feoABI systems contribute to ferric citrate acquisition in Stenotrophomonas maltophilia.Journal of biomedical science · 2022Article
- Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases.Blood advances · 2022Article
- Investigating the roles of the conserved CuJournal of inorganic biochemistry · 2020Article
- A Plasmid-Encoded FetMP-Fls Iron Uptake System Confers Selective Advantages toMicroorganisms · 2020Article
- Article
- Synthetic Biogenesis of Bacterial Amyloid Nanomaterials with Tunable Inorganic-Organic Interfaces and Electrical Conductivity.ACS synthetic biology · 2017Article
- Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen.Nature reviews. Microbiology · 2016Review
- Role of Iron Uptake Systems in Pseudomonas aeruginosa Virulence and Airway Infection.Infection and immunity · 2016Article
- Nonredundant Roles of Iron Acquisition Systems in Vibrio cholerae.Infection and immunity · 2016Article
- Virulence and Fitness Determinants of Uropathogenic Escherichia coli.Microbiology spectrum · 2015Review
- The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis.Metallomics : integrated biometal science · 2015Review
- Article
- Iron homeostasis in theAdvances in botanical research · 2013Article
- Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis.Journal of bacteriology · 2012Article
- The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague.Infection and immunity · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the uropathogenic Escherichia coli strain F11, in silico genome analysis revealed the dicistronic iron uptake operon fetMP, which is under iron-regulated control mediated by the Fur regulator. The expression of fetMP in a mutant strain lacking known iron uptake systems improved growth under iron depletion and increased cellular iron accumulation. FetM is a member of the iron/lead transporter superfamily and is essential for iron uptake by the Fet system. FetP is a periplasmic protein that enhanced iron uptake by FetM. Recombinant FetP bound Cu(II) and the iron analog Mn(II) at distinct sites. The crystal structure of the FetP dimer reveals a copper site in each FetP subunit that adopts two conformations: CuA with a tetrahedral geometry composed of His(44), Met(90), His(97), and His(127), and CuB, a second degenerate octahedral geometry with the addition of Glu(46). The copper ions of each site occupy distinct positions and are separated by ∼1.3 Å. Nearby, a putative additional Cu(I) binding site is proposed as an electron source that may function with CuA/CuB displacement to reduce Fe(III) for transport by FetM. Together, these data indicate that FetMP is an additional iron uptake system composed of a putative iron permease and an iron-scavenging and potentially iron-reducing periplasmic protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.