ArticleJournal of the American College of Cardiology2011
Association of annular calcification and aortic valve sclerosis with brain findings on magnetic resonance imaging in community dwelling older adults: the cardiovascular health study.
Article in Journal of the American College of Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Aortic stenosis intricacies beyond the valve: A bidirectional Mendelian randomization study.ESC heart failure · 2025Pooled it
- Cognitive Dysfunction and Vascular/Valvular Calcification in Patients Undergoing Peritoneal Dialysis: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Pearls and pitfalls in the diagnosis and management of mitral annular calcification.Heart (British Cardiac Society) · 2026Article
- Atherosclerosis, calcific aortic valve disease and mitral annular calcification: same or different?International journal of cardiology · 2025Review
- The heart-brain axis: unraveling the interconnections between cardiovascular and Alzheimer's diseases.Frontiers in cardiovascular medicine · 2025Review
- Association of aortic valve calcium with dementia and stroke: The Multi-Ethnic Study of Atherosclerosis.Atherosclerosis · 2024Article
- Rethinking Mitral Annular Calcification and Its Clinical Significance: From Passive Process to Active Pathology.Journal of personalized medicine · 2024Review
- Heart-brain interaction in cardiogenic dementia: pathophysiology and therapeutic potential.Frontiers in cardiovascular medicine · 2024Review
- Multimodal Cardiac Imaging in the Assessment of Patients Who Have Suffered a Cardioembolic Stroke: A Review.Journal of cardiovascular development and disease · 2023Review
- Asymptomatic Stroke in the Setting of Percutaneous Non-Coronary Intervention Procedures.Medicina (Kaunas, Lithuania) · 2021Review
- Cardiovascular damage phenotypes and all-cause and CVD mortality in older adults.Annals of epidemiology · 2021Article
- Aortic Valve Calcification Is Associated with Future Cognitive Impairment.Journal of Alzheimer's disease reports · 2021Article
- Alzheimer's Disease and Cardiovascular Disease: A Particular Association.Cardiology research and practice · 2020Review
- Prevalence and Risk Factors of Silent Brain Infarction in Patients with Aortic Stenosis.Cerebrovascular diseases extra · 2020Article
- The Role of Echocardiography Screening at the Stroke Unit.Frontiers in neurology · 2020Article
- The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment.Cellular and molecular neurobiology · 2017Review
- Cognitive decline in heart failure.Heart failure reviews · 2016Review
- The predictive value of arterial and valvular calcification for mortality and cardiovascular events.International journal of cardiology. Heart & vessels · 2014Review
- Left atrial size is independently associated with cognitive function.The International journal of neuroscience · 2013Article
- Gentamicin Reduces Calcific Nodule Formation by Aortic Valve Interstitial CellsCardiovascular engineering and technology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesThe objective of this study was to investigate the associations of mitral annular calcification, aortic annular calcification, and aortic valve sclerosis with covert magnetic resonance imaging (MRI)-defined brain infarcts.
backgroundClinically silent brain infarcts defined by MRI are associated with increased risk for cognitive decline, dementia, and future overt stroke. Left-sided cardiac valvular and annular calcifications are suspected as risk factors for clinical ischemic stroke.
methodsA total of 2,680 CHS (Cardiovascular Health Study) participants without clinical histories of stroke or transient ischemic attack underwent brain MRI in 1992 and 1993, 1 to 2 years before echocardiographic exams (1994 to 1995).
resultsThe mean age of the participants was 74.5 ± 4.8 years, and 39.3% were men. The presence of any annular or valvular calcification (mitral annular calcification, aortic annular calcification, or aortic valve sclerosis), mitral annular calcification alone, or aortic annular calcification alone was significantly associated with a higher prevalence of covert brain infarcts in unadjusted analyses (p < 0.01 for all). In models adjusted for age, sex, race, body mass index, physical activity, creatinine, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, smoking, diabetes, coronary heart disease, and congestive heart failure, the presence of any annular or valve calcification remained associated with covert brain infarcts (risk ratio: 1.24; 95% confidence interval: 1.05 to 1.47). The degree of annular or valvular calcification severity showed a direct relation with the presence of covert MRI findings.
conclusionsLeft-sided cardiac annular and valvular calcifications are associated with covert MRI-defined brain infarcts. Further study is warranted to identify mechanisms and determine whether intervening in the progression of annular and valvular calcification could reduce the incidence of covert brain infarcts as well as the associated risk for cognitive impairment and future stroke.
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Registered trials
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